Team:St Andrews

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                 <p>University of St Andrews' team for 2012 <em>International Genetically Engineered Machine competition</em></p>
                 <p>University of St Andrews' team for 2012 <em>International Genetically Engineered Machine competition</em></p>
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<p>Alternative Omega-3 production and novel metal recovery methods</p>
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<p>Alternative omega-3 production and novel metal recovery methods</p>
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<h1><a href="https://2012.igem.org/Team:St_Andrews/metal-binding">Metal binding protein</a></h1>
<h1><a href="https://2012.igem.org/Team:St_Andrews/metal-binding">Metal binding protein</a></h1>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925002”><span class="badge">BBa_K925002</span></a>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925004”><span class="badge">BBa_K925004</span></a>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925005”><span class="badge">BBa_K925005</span></a>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925006”><span class="badge">BBa_K925006</span></a></button>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925007”><span class="badge">BBa_K925007</span></a></button>
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<img src="https://static.igem.org/mediawiki/2012/9/9f/MetalBindingLogo_100.png" align="left" />                 
<img src="https://static.igem.org/mediawiki/2012/9/9f/MetalBindingLogo_100.png" align="left" />                 
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<p>Precious and toxic metals from car catalysts frequently find their way into the
<p>Precious and toxic metals from car catalysts frequently find their way into the
environment. By developing metal-binding proteins, we can reverse metal aggregation on our roads. This not only reduces the environmental impact of personal transportation, but will proffer a new man-made mine of precious metals.</p>
environment. By developing metal-binding proteins, we can reverse metal aggregation on our roads. This not only reduces the environmental impact of personal transportation, but will proffer a new man-made mine of precious metals.</p>
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<h1><a href="https://2012.igem.org/Team:St_Andrews/Omega-3-synthesis">ω−3 Fatty acids synthesis</a></h1>
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<h1><a href="https://2012.igem.org/Team:St_Andrews/Omega-3-synthesis">ω−3 fatty acids synthesis</a></h1>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925000”><span class="badge">BBa_K925000</span></a>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925001”><span class="badge">BBa_K925001</span></a>
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<a href=”http://partsregistry.org/wiki/index.php?title=Part:BBa_K925003”><span class="badge">BBa_K925003</span></a>
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<img src="https://static.igem.org/mediawiki/2012/5/57/OmegaThreeLogo_100.png" align="left" />                 
<img src="https://static.igem.org/mediawiki/2012/5/57/OmegaThreeLogo_100.png" align="left" />                 
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           <p>     ω-3 Fatty acids are an essential component of our diet and are paramount to maintaining human health. Our team is recreating a synthetic pathway for this nutrient in E. coli, using genes from the cyanobacteria <i>Synechocystis</i> and the trypanosomatid <i>Leishmania major</i>. Combining the DNA code for elongase and desaturase enzymes, we can convert the plain fatty acid of E. coli into highly valuable ω-3 fatty acids.  
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           <p>ω-3 fatty acid is a key component of the healthy human diet. The nutrient is only synthesized naturally in a handful of organisms (algae and oil-rich plants). Our team partially recreated the pathway for ω-3 production in <i>E. coli</i> using genes from the cyanobacteria <i>Synechocystis</i>, despite the difficulty of working with membrane-bound proteins. Until now, synthetic ω-3 production has only been achieved in plants.
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<h1><a href="https://2012.igem.org/Team:St_Andrews/Modelling">Modelling ω−3 depletion</a></h1>
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<h1><a href="https://2012.igem.org/Team:St_Andrews/Modelling">The mathematics of ω-3</a></h1>
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<img src="https://static.igem.org/mediawiki/2012/f/f0/ModSquadLogo_100.png" align="left" />
<img src="https://static.igem.org/mediawiki/2012/f/f0/ModSquadLogo_100.png" align="left" />
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                 <p>We use mathematical modelling to take a closer look at marine biomass depletion and how this affects natural ω-3 stock. Using this model, we investigate the global effects of industrial omega-3 from syntehtic sources. At what rate must the production be instituted to preserve marine wildlife diversity? What are the consequences of persistently ignoring this problem?</p>
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                 <p>We modelled fish population dynamics. Our result: if we continue fishing in the current manner, by 2100, only a fraction of present day biomass will remain. Yet, there is hope.  Indeed, realizing Team St Andrews' alternative production of omega-3 could be the measure necessary to save our seas. We investigated the effect that alternative production can have on future fish biomass, as well as the practicalities of preserving life in this manner.</p>
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                         <li class="span3"><a href="http://www.lgcstandards.com/" class="thumbnail"><img src="http://dl.dropbox.com/u/491730/iGEm/images/sponsors/LGC.jpg" alt=""></a></li>
                         <li class="span3"><a href="http://www.lgcstandards.com/" class="thumbnail"><img src="http://dl.dropbox.com/u/491730/iGEm/images/sponsors/LGC.jpg" alt=""></a></li>
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                         <li class="span3"><a href="http://www.sulsa.ac.uk" class="thumbnail"><img src="http://dl.dropbox.com/u/491730/iGEm/images/sponsors/SULSA%20logo.jpg" alt=""></a></li>
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                     <h1>iGEM</h1>
                     <h1>iGEM</h1>
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                     <p>The International Genetically Engineered Machine competition (iGEM) is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. This project design and competition format is an exceptionally motivating and effective teaching method.</p>
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                     <p>The International Genetically Engineered Machine competition (iGEM) is the premier undergraduate synthetic biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. This project design and competition format is an exceptionally motivating and effective teaching method.</p>
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<h4 class="alert-heading">Offline project summaries</h4>
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These are the downloadable versions of our project summaries:
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                     <h1>Twitter</h1><br>
                     <h1>Twitter</h1><br>
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Latest revision as of 02:02, 23 October 2012

St Andrews iGEM '12

StA iGEM Wiki 2012 - Home

source

University of St Andrews' team for 2012 International Genetically Engineered Machine competition

Alternative omega-3 production and novel metal recovery methods

University of St Andrews coat of arms

Metal binding protein

BBa_K925002 BBa_K925004 BBa_K925005 BBa_K925006 BBa_K925007

Precious and toxic metals from car catalysts frequently find their way into the environment. By developing metal-binding proteins, we can reverse metal aggregation on our roads. This not only reduces the environmental impact of personal transportation, but will proffer a new man-made mine of precious metals.

ω−3 fatty acids synthesis

BBa_K925000 BBa_K925001 BBa_K925003

ω-3 fatty acid is a key component of the healthy human diet. The nutrient is only synthesized naturally in a handful of organisms (algae and oil-rich plants). Our team partially recreated the pathway for ω-3 production in E. coli using genes from the cyanobacteria Synechocystis, despite the difficulty of working with membrane-bound proteins. Until now, synthetic ω-3 production has only been achieved in plants.


Scientific impact of iGEM

We investigate the relationship between the iGEM competition and the rest of the scientific community. Is iGEM really having scientific impact? How often, how fairly and by whom are iGEM teams cited? Does the iGEM competition result in scholarly articles being published? What can guarantee continued recognition within the SynBio community?


The mathematics of ω-3

We modelled fish population dynamics. Our result: if we continue fishing in the current manner, by 2100, only a fraction of present day biomass will remain. Yet, there is hope. Indeed, realizing Team St Andrews' alternative production of omega-3 could be the measure necessary to save our seas. We investigated the effect that alternative production can have on future fish biomass, as well as the practicalities of preserving life in this manner.

Sponsors

iGEM

The International Genetically Engineered Machine competition (iGEM) is the premier undergraduate synthetic biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. This project design and competition format is an exceptionally motivating and effective teaching method.

×

Offline project summaries

These are the downloadable versions of our project summaries:

Twitter


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University of St Andrews, 2012.

Contact us: igem2012@st-andrews.ac.uk, Twitter, Facebook

This iGEM team has been funded by the MSD Scottish Life Sciences Fund. The opinions expressed by this iGEM team are those of the team members and do not necessarily represent those of Merck Sharp & Dohme Limited, nor its Affiliates.

Retrieved from "http://2012.igem.org/Team:St_Andrews"