Team:TU-Eindhoven

• Introduction
  • Home page
  • Background
    information
  • About us
  • Contact us
  • Our photos
• Project
  • Project description
  • Lab approach
  • Device information
  • Initial model
  • Yeast model
  • Lab results
  • Our BioBricks^TM
  • Our
    accomplishments
• Considerations
  • Public outreach
  • Safety questions
  • Other thoughts
• Future applications
  • Human interest
  • Further
    developments
• Notebook
  • Before week 1
  • Week 1
  • Week 2
  • Week 3
  • Week 4
  • Week 5
  • Week 6
  • Week 7
  • Week 8
  • Week 9
  • Week 10
  • Week 11
  • Week 12
  • After week 12
  • Lab protocols
• Partners
  • ICMS TU/e
  • Team collaborations
  • Attributions and Contributions
  • Our sponsors

A team of students from different departments of the Eindhoven University of Technology participates in the International Genetically Engineered Machine competition 2012, a synthetic biology competition for undergraduate students. The aim of the project is to design and produce a multi-color display, in which genetically engineered yeast cells function as pixels. Calcium ions enter a yeast cell when electrically stimulated, which in turn can trigger a fluorescent response through a genetically engineered calcium sensor protein. This will require a thorough understanding of calcium homeostasis in yeast cells. To explore the calcium metabolism, enable the induction of fluorescence and control this fluorescence, laboratory work will be combined with computational modeling and the engineering of a control device. The team envisions a yeast cell that is able to emit light when probed by an electrical stimulus: the Light Emitting Cell (LEC). The aim of this project therefore is to engineer and build a prototype display from LECs.