Team:Freiburg

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Revision as of 09:14, 8 May 2012

The iGEM Team Freiburg 2012 (FreiGEM) is dedicated to standardize the synthesis of Transactivator-like (TAL) proteins, i.e. DNA-binding proteins. In contrast to zinc-finger proteins they consist of domain-like repeats in their primary structure that differ only by two amino acids. These two amino acids of a given repeat determine which DNA base the repeat will bind to. By providing efficient mechanisms to combine the different repeats in order to target a certain DNA sequence of around 14bp the FreiGEM team is working towards establishing a standardized kit. This one tube essay will provide the user with an easy, quick and cost-efficient way to design his or her individualized TAL protein in just a glance. However, FreiGEM 2012 will not stop there but move beyond that by also including different TAL effectors in the kit. These are enzymes that can be linked to the DNA-binding domain and thereby act only around a specific region in the genome - perefectly suited for epigenetic application, for instance by using histone modifying enzymes.
Stay tuned to FreiGEM 2012 - we will keep you in the loop.	File:Freiburg team.png Your team picture
	Team Freiburg

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+|The iGEM Team Freiburg 2012 (FreiGEM) is dedicated to standardize the synthesis of Transactivator-like (TAL) proteins, i.e. DNA-binding proteins. In contrast to zinc-finger proteins they consist of domain-like repeats in their primary structure that differ only by two amino acids. These two amino acids of a given repeat determine which DNA base the repeat will bind to. By providing efficient mechanisms to combine the different repeats in order to target a certain DNA sequence of around 14bp the FreiGEM team is working towards establishing a standardized kit. This one tube essay will provide the user with an easy, quick and cost-efficient way to design his or her individualized TAL protein in just a glance. However, FreiGEM 2012 will not stop there but move beyond that by also including different TAL effectors in the kit. These are enzymes that can be linked to the DNA-binding domain and thereby act only around a specific region in the genome - perefectly suited for epigenetic application, for instance by using histone modifying enzymes.
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-''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+''Stay tuned to FreiGEM 2012 - we will keep you in the loop.''
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 !align="center"|[[Team:Freiburg|Home]]
 !align="center"|[[Team:Freiburg/Team|Team]]