Team:USTC-China

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This year, USTC-China iGEMers are providing a novel immune system for engineering bacteria to fight against the bacteriophage. We hope this artificial line of defeat with gene circuits can be of practical use in fermentation industry.
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Since the fermentation industry occurred, the bacteriophage has become a big threat to engineering bacteria. During mass producing dairy products, enzymes, amino acids, antibiotics and pesticides, once the bacteria are infected by bacteriophage, the results are unimaginable. The bacteria will die abnormally and the infection will spread quickly. Without any efficient action, tremendous loss will lie ahead. Nowadays, common strategies for avoiding this catastrophe is to control the condition of the fermentation strictly. Also, people keep selecting strains against phages. But all the strategies are time consuming and far from once for all.
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However, the engineering bacteria 2012 USTC-China iGEMers hope to cultivate can both protect themselves when bacteriophage invades the strain and focus on producing products without consuming extra energy when their living environment is safe. In this case, the quality of fermented products can be guaranteed and the profits of fermentation industry can be enormously improved.
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  <a href="https://2012.igem.org/Team:USTC-China">Home
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  <a href="https://2012.igem.org/Team:USTC-China/background">Project
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  <h3>lambda phage</h3>
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  <li id="kwick_3">
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  <a href="https://2012.igem.org/Team:USTC-China/results">Achievements
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  <h3>What we get</h3>
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  <a href="https://2012.igem.org/Team:USTC-China/modeling">Modeling
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  <h3>Analytic</h3>
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  <a href="https://2012.igem.org/Team:USTC-China/outreach">Outreach
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  <a href="https://2012.igem.org/Team:USTC-China/protocols">Notes
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  <a href="https://2012.igem.org/Team:USTC-China/team">Team
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<P>WELCOME TO THE WIKI OF USTC-CHINA IGEM TEAM! ENJOY YOUR EXPLORATION!</P>
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<a href="https://2012.igem.org/Team:USTC-China/parts" class="one">PARTS</a>
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<p class="button">This summer we have contributed 22 parts to the partsregistry!</p>
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<div id="option2" >
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<a href="https://2012.igem.org/Team:USTC-China/modeling">MODELING</a>
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<p class="button">We have theoretically analysed our system through Mathematical Modeling!</p>
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<div id="option3" >
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<a href="https://2012.igem.org/Team:USTC-China/outreach">OUTREACH</a>
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<p class="button">Our team have conducted several activities for public recognition of synthetic biology!</p>
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<div id="option4">
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<a href="https://2012.igem.org/Team:USTC-China/safety">SAFETY</a>
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<p class="button">The project is considered to have the minimal risks!</p>
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<a href="https://2012.igem.org/Team:USTC-China/team">TEAM</a>
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<p class="button2">Members in USTC_China enjoyed themselves this summer!</p>
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<h3>WELCOME!</h3>
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<p class="project">Bacteriophage is one of the severest threats to fermentation factories. To help solve the problem, we design a gene circuit which can both sense and defend against phages. We use the modified promoter pRM to sense the phage’s infection and initiate the defence. The lysis gene which can make bacteria lyse is installed to our circuit. When it works, the phage won’t be able to take advantage of its host to replicate any longer. To win more time for lysis to function well, we design an antisense RNA to prevent the phage from turning into lytic life cycle. Thus, when the lysis protein kills the host, the phage is still at lysogenic life cycle or the newly assembled phages are still immature. By using the quorum sensing system, the bacteria around the host can make well preparation to defend in advance. Attribute to these parts, our bacteria survive.</p>
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<p class="button"><a href="https://2012.igem.org/Team:USTC-China/background">more</a></p>
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<div id="ustcsponsor" >
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  <p class="big">SPONSORS</p></br>
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  <a href="http://china.db.com/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/0/0c/Deutsche_bank.jpg" /></a>
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  <a href="http://www.ustcif.org/" ><img src="https://static.igem.org/mediawiki/2012/3/36/Ustcif.jpg" style="height:99px;width:98px;float:left;margin-left:10px;"/></a>
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  <a href="http://en.gradschool.ustc.edu.cn/" ><img src="https://static.igem.org/mediawiki/2012/7/79/GRADUATE.png" style="float:left;margin-left:10px;"/></a>
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  <a href="http://www.teach.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/7/79/Teaching.jpg" /></a>
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  <a href="http://en.biox.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/archive/5/5e/20120830175936%21Life.jpg" /></a>
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  <a href="http://en.physics.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/a/ac/Phy.png" /></a>
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  <a href="http://en.scgy.ustc.edu.cn/" ><img src="https://static.igem.org/mediawiki/2012/f/f1/Gifted_young.jpg" style="width:330px;height:85px;float:left;margin-left:10px;"/></a>
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Latest revision as of 03:21, 28 September 2013

WELCOME TO THE WIKI OF USTC-CHINA IGEM TEAM! ENJOY YOUR EXPLORATION!

PARTS

This summer we have contributed 22 parts to the partsregistry!

MODELING

We have theoretically analysed our system through Mathematical Modeling!

OUTREACH

Our team have conducted several activities for public recognition of synthetic biology!

SAFETY

The project is considered to have the minimal risks!

TEAM

Members in USTC_China enjoyed themselves this summer!

WELCOME!

Bacteriophage is one of the severest threats to fermentation factories. To help solve the problem, we design a gene circuit which can both sense and defend against phages. We use the modified promoter pRM to sense the phage’s infection and initiate the defence. The lysis gene which can make bacteria lyse is installed to our circuit. When it works, the phage won’t be able to take advantage of its host to replicate any longer. To win more time for lysis to function well, we design an antisense RNA to prevent the phage from turning into lytic life cycle. Thus, when the lysis protein kills the host, the phage is still at lysogenic life cycle or the newly assembled phages are still immature. By using the quorum sensing system, the bacteria around the host can make well preparation to defend in advance. Attribute to these parts, our bacteria survive.


more

SPONSORS


backtotop

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