Team:LMU-Munich/Data/differentiation

From 2012.igem.org

Bacillus in urban culture.jpg

The LMU-Munich team is exuberantly happy about the great success at the World Championship Jamboree in Boston. Our project Beadzillus finished 4th and won the prize for the "Best Wiki" (with Slovenia) and "Best New Application Project".

Sporenfreunde

Bacillus introduction banner.resized WORDS.JPG

Differentiation

B. subtilis is able to differentiate into cells with different morphologies and functions (Fig. 3). The most characteristic form is the endospore, which is produced under nutrient starvation. In our project, we exploited the production of endospores. Because they are extremely stable, spores are perfect vehicles for the display of functional fusion proteins on their surface as illustrated by our Sporobead module.

Figures Bacillus Intro fig1.png

Fig. 3: The vegetative cycle is very similiar to that of E. coli. However, in the event of a stressor such as starvation, the cells enter sporulation, where they first undergo a polar cell division, followed by the formation of the endospore. If the environmental conditions are suitable again, the spore will then germinate and reenter the vegetative cycle.

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