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| | <h1>Welcome to our French Froggies project</h1> | | <h1>Welcome to our French Froggies project</h1> |
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| - | <img src="http://pierreyves8.free.fr/300px-Frogncorn.png" alt="evry team logo"/><br/>
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| - | <em>We are working on this wiki along with the advancement of our project, so come again soon to see the project and the wiki evolving!</em>
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| - | </center>
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| - | <h2>Project</h2>
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| - | <p>Building on a long-standing French fascination for frogs, we wanted to spread this enthusiasm to the world of synthetic biology by introducing a new, vertebrate chassis to the community: <i>Xenopus tropicalis</i>. This leap towards multicellular biological engineering required new tools, so we first developed a new set of frog compatible vectors, biobricked tissue specific promoters and a new technique to assemble them in a single shot. To benefit from tissue compartmentalisation, we created a synthetic, orthogonal hormonal system using the plant molecule auxin. We also investigated E. coli/Xenopus interfacing, effectively creating a synthetic ecosystem. We modelled our system at the organism scale, using a multi-level and multi-technique approach. Finally, working with whole animals during iGEM brought a load of difficult ethical questions regarding animal biotechnologies and experimentation. This led us to wonder: Are we a chassis?</p>
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| - | <p> Visit our <a href="https://2012.igem.org/Team:Evry/Project">project</a> to understand deeper what we are working on. </p>
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| - | <h2>Composition of our team</h2>
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| - | <img src="https://static.igem.org/mediawiki/2012/thumb/a/a0/Modelisateurs.jpg/400px-Modelisateurs.jpg" alt="some modelers working" />
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| - | </center>
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| - | <p>The composition of our team is available.<a href="https://2012.igem.org/Team:Evry/Team"> Click here to visit our team page</a></p>
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| - | <h2>Achievements</h2>
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| - | <p>This is the list of the acheivement of our team working. Click on the elements of the list to get to the page:</p>
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| - | <ul>
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| - | <li>We have created the first biobrick parts to work in <i>Xenopus tropicalis</i>, and most of our new parts have enhanced expression in mammalian and other vertebrates cells</li>
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| - | <li>We have developped a new methodology to model the physiology of a vertebrate at the organism scale</li>
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| - | <li>We have been exploring the ethical and social impact of engineering living animals</li>
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| - | <li>... To be completed</li>
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| - | </ul>
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