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Team:XMU-China/modeling
From 2012.igem.org
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Model
Introduction
Ordinary differential equation(s) (ODE) is one of the most popular methods in modeling. Frank R. Giordano and other scientists have introduced it exhaustively. [1] In many computational biological researching, researchers often use it to simulate the dynamics part of biological process. The concentrations of RNA, proteins, and other molecules are represented by time-dependent variables. [2] We used the same method to construct our model.
Modeling
First of all, there are 4 variables and 4 parameters in this experience. Their names and meanings are listed below.
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Cell Immobilization
We have almost finished building our display device, just a few more running tests are needed to improve and perfect it. We plan to immobilize cells that contain other genetic circuits we constructed and stuff them correspondingly into the seven glass tubes. The transportation system of oxygenated medium is also needed perfection. After some optimizing experiments, we can finally accomplish our digital display device.
E-ink
“What will we get in this project?” We have been asked for many times but still have no idea, until an E-book displayed on our lab. We were inspired by this magical device and got our answer.
E-book is a book-length publication in digital form, consisting of text, images, or both, and produced on, published through, and readable on computers or other electronic devices.[1] Its core is E-ink. E-ink is a specific proprietary type of electronic paper manufactured by E-Ink Corporation, founded in 1997 based on research started at the MIT Media Lab. However, E-ink has some shortcoming, like it just can display monochromatic figure. But, the E.coli in our project in this year can replaced the E ink. And the microcapsules, which are used for nurturing bacteria, can also replace the pearls, which are used for carrying ink. We concluded all above for 4 reasons.
- Digital display and E ink share the same working principle;
- There are both microcapsules on their solution;
- We can control their station by controlling the input signal;
- Comparing monochromatic E-ink, we can construct different logical circuits in the engineering bacteria, and add different inducer. Then the bacteria will generate chromatic GFP. In another word, we could create multicolor E-book.
In a word, if we can improve technology, the digital display will probably replace the traditional E-ink.
Reference
[1]Chen, B.-S. and C.-H. Wu. A systematic design method for robust synthetic biology to satisfy design specifications[J]. BMC Systems Biology, 2009, 3(1): 66.
