Team:UCSF/Modeling

From 2012.igem.org

(Difference between revisions)
Line 11: Line 11:
<img style = "margin-bottom:35px"src="https://dl.dropbox.com/u/24404809/iGEM%202012/igem%202012%20website%20photos/Modeling/Modeling1.jpg">
<img style = "margin-bottom:35px"src="https://dl.dropbox.com/u/24404809/iGEM%202012/igem%202012%20website%20photos/Modeling/Modeling1.jpg">
<br><p>
<br><p>
-
<regulartext>Our goal is to get a steady ratio of the two strains’ populations, which is neither too large nor too small. Firstly, we did mathematical analysis based on the ODEs above; then we did simulation of this system. What’s more, we also searched suitable parameters which could make the system go to a steady ratio of the two strains to test the robustness of this system. At last, we did a sensitivity analysis which could tell us which parameter is sensitive if we want to get a steady ratio.
+
<regulartext>Our goal is to get a steady ratio of the two strains’ populations, which is neither too large nor too small. First, we did mathematical analysis based on the ODEs above; then we performed a simulation of this system. What’s more, we also searched suitable parameters which could make the system go to a steady ratio of the two strains to test the robustness of this system. Finally, we did a sensitivity analysis which could tell us which parameter is sensitive if we want to get a steady ratio.
<br><p>
<br><p>
<regulartext>
<regulartext>
Reference <br>
Reference <br>
[1] Alissa Kerner, Jihyang Park, Audra Williams, Xiaoxia Nina Lin “A Programmable Escherichia coli Consortium via Tunable Symbiosis”,Plos One, March 2012 | Volume 7 | Issue 3 | e34032.
[1] Alissa Kerner, Jihyang Park, Audra Williams, Xiaoxia Nina Lin “A Programmable Escherichia coli Consortium via Tunable Symbiosis”,Plos One, March 2012 | Volume 7 | Issue 3 | e34032.

Revision as of 00:05, 3 October 2012


Modeling of the Auxotroph System

**A summary of our modeling work is shown on this page and a detailed analysis can be downloaded HERE


Our goal is to get a steady ratio of the two strains’ populations, which is neither too large nor too small. First, we did mathematical analysis based on the ODEs above; then we performed a simulation of this system. What’s more, we also searched suitable parameters which could make the system go to a steady ratio of the two strains to test the robustness of this system. Finally, we did a sensitivity analysis which could tell us which parameter is sensitive if we want to get a steady ratio.

Reference
[1] Alissa Kerner, Jihyang Park, Audra Williams, Xiaoxia Nina Lin “A Programmable Escherichia coli Consortium via Tunable Symbiosis”,Plos One, March 2012 | Volume 7 | Issue 3 | e34032.