http://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&feed=atom&action=historyTeam:Slovenia/SocietyScientists - Revision history2024-03-28T14:28:11ZRevision history for this page on the wikiMediaWiki 1.16.0http://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=289522&oldid=prevUrbanB at 20:51, 26 October 20122012-10-26T20:51:42Z<p></p>
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<td colspan='2' style="background-color: white; color:black;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 20:51, 26 October 2012</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchDesignedTALregulators'><span>Designed TAL regulators</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchDesignedTALregulators'><span>Designed TAL regulators</span></a></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchPositiveFeedbackLoopSwitch'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Positive feedback loop switch</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchPositiveFeedbackLoopSwitch'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/TheSwitchPositiveFeedbackLoopSwitch';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Positive feedback loop switch</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchControls'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Controls</span></td><td class="newtable"><img style="margin-right:-81px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchControls'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/TheSwitchControls';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Controls</span></td><td class="newtable"><img style="margin-right:-81px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsEscapeTag'><span>Escape tag</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsEscapeTag'><span>Escape tag</span></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsTermination'><span>Termination</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsTermination'><span>Termination</span></a></li> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href=<del class="diffchange diffchange-inline">'</del>https://2012.igem.org/Team:Slovenia/SafetyMechanismsMicrocapsuleDegradation<del class="diffchange diffchange-inline">'</del>><table class="newtable"><tr class="newtable"><td class="newtable"><span>Microcapsule degradation</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href=<ins class="diffchange diffchange-inline">"</ins>https://2012.igem.org/Team:Slovenia/SafetyMechanismsMicrocapsuleDegradation<ins class="diffchange diffchange-inline">"</ins>><table <ins class="diffchange diffchange-inline"> onclick="window.location = 'https://2012.igem.org/Team:Slovenia/SafetyMechanismsMicrocapsuleDegradation';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Microcapsule degradation</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationHepatitisC'><span>Hepatitis C</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationHepatitisC'><span>Hepatitis C</span></a></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationIschaemicHeartDisease'><span>Ischaemic heart disease</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationIschaemicHeartDisease'><span>Ischaemic heart disease</span></a></li> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationImpact'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Impact</span></td><td class="newtable"><img style="margin-right:-86px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationImpact'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/ImplementationImpact';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Impact</span></td><td class="newtable"><img style="margin-right:-86px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/Modeling'><span>Overview</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/Modeling'><span>Overview</span></a></li></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingPK'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Pharmacokinetics</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingPK'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/ModelingPK';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Pharmacokinetics</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMethods'><span>Modeling methods</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMethods'><span>Modeling methods</span></a></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingPositiveFeedbackLoopSwitch'><span>Positive feedback loop switch</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingPositiveFeedbackLoopSwitch'><span>Positive feedback loop switch</span></a></li> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingQuantitativeModel'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Experimental model</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingQuantitativeModel'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/ModelingQuantitativeModel';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Experimental model</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingInteractiveSimulations'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Interactive simulations</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingInteractiveSimulations'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/ModelingInteractiveSimulations';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Interactive simulations</span></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </li></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/Notebook'><span>Experimental methods</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/Notebook'><span>Experimental methods</span></a></li></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/NotebookLablog'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Lablog</span></td><td class="newtable"><img style="margin-right:-90px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/NotebookLablog'><table <ins class="diffchange diffchange-inline">onclick="window.location = 'https://2012.igem.org/Team:Slovenia/NotebookLablog';" </ins>class="newtable"><tr class="newtable"><td class="newtable"><span>Lablog</span></td><td class="newtable"><img style="margin-right:-90px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/NotebookLabSafety'><span>Lab safety</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/NotebookLabSafety'><span>Lab safety</span></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> </ul></div></td></tr>
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</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=282290&oldid=prevUrbanB at 08:12, 26 October 20122012-10-26T08:12:48Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> For this purpose, blocking the cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> For this purpose, blocking the cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of <del class="diffchange diffchange-inline">pro-drugs </del>to terminate cells seems to be the safest mechanism,</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of <ins class="diffchange diffchange-inline">prodrugs </ins>to terminate cells seems to be the safest mechanism,</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> although it may be advantageous to select compounds less toxic than ganciclovir that have a higher therapeutic index and have as little as possible effect on host cells. We may have to increase the enzymatic activity of alginate lyase for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and a sensitization of the organism to a repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in all other applications of microencapsulated cells. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> although it may be advantageous to select compounds less toxic than ganciclovir that have a higher therapeutic index and have as little as possible effect on host cells. We may have to increase the enzymatic activity of alginate lyase for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and a sensitization of the organism to a repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in all other applications of microencapsulated cells. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td></tr>
</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=280286&oldid=prevDusanv at 00:00, 26 October 20122012-10-26T00:00:52Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TeamGallery'><span>Gallery</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TeamGallery'><span>Gallery</span></a></li> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TeamSponsors'><span>Sponsors</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TeamSponsors'><span>Sponsors</span></a></li> </div></td></tr>
</table>Dusanvhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=279131&oldid=prevStrazkosann at 17:38, 25 October 20122012-10-25T17:38:00Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><a style="position:absolute; top:0px; left:490px;" href="https://2012.igem.org/Main_Page"><b>iGEM 2012</b></a></del></div></td><td colspan="2"> </td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/TheSwitchMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li> </div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsEscapeTag'><span>Escape tag</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsEscapeTag'><span>Escape tag</span></a></li> </div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> </del><li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsMicrocapsuleDegradation'><span>Microcapsule degradation</span></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"> </ins><li><a href='https://2012.igem.org/Team:Slovenia/SafetyMechanismsMicrocapsuleDegradation'<ins class="diffchange diffchange-inline">><table class="newtable"><tr class="newtable"><td class="newtable"</ins>><span>Microcapsule degradation</span<ins class="diffchange diffchange-inline">></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table</ins>></a></li> </div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationHepatitisC'><span>Hepatitis C</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationHepatitisC'><span>Hepatitis C</span></a></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationIschaemicHeartDisease'><span>Ischaemic heart disease</span></a></li> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationIschaemicHeartDisease'><span>Ischaemic heart disease</span></a></li> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"> <li><a href='https://2012.igem.org/Team:Slovenia/ImplementationImpact'><table class="newtable"><tr class="newtable"><td class="newtable"><span>Impact</span></td><td class="newtable"><img style="margin-right:-86px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table></a></li> </ins></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingMutualRepressorSwitch'><span>Mutual repressor switch</span></a></li></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingQuantitativeModel'><span><del class="diffchange diffchange-inline">Quantitative and stability </del>model</span></a></li> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> <li><a href='https://2012.igem.org/Team:Slovenia/ModelingQuantitativeModel'<ins class="diffchange diffchange-inline">><table class="newtable"><tr class="newtable"><td class="newtable"</ins>><span><ins class="diffchange diffchange-inline">Experimental </ins>model</span<ins class="diffchange diffchange-inline">></td><td class="newtable"><img style="margin-right:-15px;" width="25px" src="https://static.igem.org/mediawiki/2012/e/ee/Svn12_hp_new.png"></img></td></tr></table</ins>></a></li> </div></td></tr>
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</table>Strazkosannhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=221822&oldid=prevUrbanB at 22:46, 26 September 20122012-09-26T22:46:02Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We therefore <del class="diffchange diffchange-inline">includ </del>some thoughts on our project and its continuation and extension. We included some discussion</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We therefore <ins class="diffchange diffchange-inline">include </ins>some thoughts on our project and its continuation and extension. We included some discussion</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on <ins class="diffchange diffchange-inline"><a href="https://2012.igem.org/Team:Slovenia/Implementation"></ins>Implementation<ins class="diffchange diffchange-inline"></a></ins>. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>The results of our project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>The results of our project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td></tr>
</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=220995&oldid=prevUrbanB at 22:29, 26 September 20122012-09-26T22:29:16Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of cancer). On the 20th of July 2012 the European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of cancer). On the 20th of July 2012 the European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> opinion that recommends the first gene therapy for approval. These reports encourage and convince us that the realization of clinical</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> opinion that recommends the first gene therapy for approval. These reports encourage and convince us that the realization of clinical</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> potentials of synthetic biology is not so far in the future, but we are aware that the speed of implementing new therapies must be <del class="diffchange diffchange-inline">balanced</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> potentials of synthetic biology is not so far in the future, but we are aware that the speed of implementing new therapies must be <ins class="diffchange diffchange-inline">determined by elimination of all safety concerns</ins>. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"> with extreme caution</del>. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h2 style="color:grey;">References</h2></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h2 style="color:grey;">References</h2></div></td></tr>
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</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=220908&oldid=prevUrbanB at 22:27, 26 September 20122012-09-26T22:27:38Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>as this may make it more difficult to exactly asses the amount of the produced drug and therefore the amount of microcapsules that would need </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>as this may make it more difficult to exactly asses the amount of the produced drug and therefore the amount of microcapsules that would need </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>to be implanted. Clearly the use of therapeutics that allow sufficiently broad range of effective therapeutic concentrations would be </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>to be implanted. Clearly the use of therapeutics that allow sufficiently broad range of effective therapeutic concentrations would be </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>preferable. For therapy of acute diseases (e.g. <del class="diffchange diffchange-inline">a </del>myocardial infarction) where microcapsules would need to perform their task only for several</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>preferable. For therapy of acute diseases (e.g. myocardial infarction) where microcapsules would need to perform their task only for several</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> weeks it would most likely be sufficient to have a finite amount of stably transfected, nondividing cells within the microcapsule. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> weeks it would most likely be sufficient to have a finite amount of stably transfected, nondividing cells within the microcapsule. </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> For this purpose blocking the cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> For this purpose<ins class="diffchange diffchange-inline">, </ins>blocking the cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of pro-drugs to terminate cells seems to be the safest mechanism,</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of pro-drugs to terminate cells seems to be the safest mechanism,</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> although it may be advantageous to select less toxic <del class="diffchange diffchange-inline">compounds </del>than ganciclovir that have a higher therapeutic index and as little as possible effect on host cells. We may have to increase the enzymatic activity of alginate lyase for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and a sensitization of the organism to a repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in all other applications of microencapsulated cells. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> although it may be advantageous to select <ins class="diffchange diffchange-inline">compounds </ins>less toxic than ganciclovir that have a higher therapeutic index and <ins class="diffchange diffchange-inline">have </ins>as little as possible effect on host cells. We may have to increase the enzymatic activity of alginate lyase for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and a sensitization of the organism to a repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in all other applications of microencapsulated cells. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> cells. Our <b>pharmacokinetic model</b> should prove as a valuable tool that will allow us to adjust the parameters to improve the model </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> cells. Our <b>pharmacokinetic model</b> should prove as a valuable tool that will allow us to adjust the parameters to improve the model </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> even further and estimate the concentration of therapeutics in different tissues on <del class="diffchange diffchange-inline">the basis of </del>the level of therapeutics in the serum. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> even further and estimate the concentration of therapeutics in different tissues <ins class="diffchange diffchange-inline">based </ins>on the level of therapeutics in the serum. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Clinical trials</b> will have to meet all medical, ethical and regulatory requirements. The first clinical trials of applications </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Clinical trials</b> will have to meet all medical, ethical and regulatory requirements. The first clinical trials of applications </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>based on synthetic biology tools are already underway (Bugaj and Schaffer, 2012; devices controlling interleukin-12 production for the treatment</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>based on synthetic biology tools are already underway (Bugaj and Schaffer, 2012; devices controlling interleukin-12 production for the treatment</div></td></tr>
</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=220446&oldid=prevUrbanB at 22:18, 26 September 20122012-09-26T22:18:59Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><td class="summary"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><td class="summary"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><!-- VSEBINA OD TU DALJE --></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><!-- VSEBINA OD TU DALJE --></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>Development of a new technology brings with it the responsibility to consider its potential risks, taking into account <del class="diffchange diffchange-inline">all </del>the ethical <del class="diffchange diffchange-inline">and </del>environmental concerns arising from the rapid progress of synthetic biology. It is also our responsibility to promote the development and public acceptance of synthetic biology, which has potentials to improve the quality of life. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Development of a new technology brings with it the responsibility to consider its potential risks, taking into account the ethical<ins class="diffchange diffchange-inline">, </ins>environmental <ins class="diffchange diffchange-inline">and other </ins>concerns arising from the rapid progress of synthetic biology. It is also our responsibility to promote the development and public acceptance of synthetic biology, which has potentials to improve the quality of life. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Among the stakeholders, scientists play an important role in the social dimension of our inventions (Figure 1). Scientific assessment of any new technology is a very important prerequisite before its translation into tangible applications and its dissemination. As the inventors we have to examine the results from the scientific point of view ourselves but it will also be subjected to peer review by other scientists, first at the iGEM competition and later in the form of scientific publications, which we expect will follow shortly. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Among the stakeholders, scientists play an important role in the social dimension of our inventions (Figure 1). Scientific assessment of any new technology is a very important prerequisite before its translation into tangible applications and its dissemination. As the inventors we have to examine the results from the scientific point of view ourselves but it will also be subjected to peer review by other scientists, first at the iGEM competition and later in the form of scientific publications, which we expect will follow shortly. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We <del class="diffchange diffchange-inline">are </del>therefore <del class="diffchange diffchange-inline">including </del>some thoughts on our project and its continuation and extension. We <del class="diffchange diffchange-inline">have already </del>included <del class="diffchange diffchange-inline">the </del>discussion</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We therefore <ins class="diffchange diffchange-inline">includ </ins>some thoughts on our project and its continuation and extension. We included <ins class="diffchange diffchange-inline">some </ins>discussion</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>The results of <del class="diffchange diffchange-inline">this </del>project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>The results of <ins class="diffchange diffchange-inline">our </ins>project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Those devices could and should be further tailored for different applications. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Those devices could and should be further tailored for different applications. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>For the actual therapeutic implementation we would clearly need to prepare <del class="diffchange diffchange-inline">a </del>stably transfected cell <del class="diffchange diffchange-inline">line </del>with versions</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>For the actual therapeutic implementation we would clearly need to prepare stably transfected cell <ins class="diffchange diffchange-inline">lines </ins>with versions</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of our proposed therapeutic device. Introduction of so many different parts into the genome will be a considerable task. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of our proposed therapeutic device. Introduction of so many different parts into the genome will be a considerable task. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>We also pondered on the issue of whether we should allow cells to divide inside the microcapsules or prevent the division, </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>We also pondered on the issue of whether we should allow cells to divide inside the microcapsules or prevent the division, </div></td></tr>
</table>UrbanBhttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=199429&oldid=prevMiha Jerala at 14:28, 26 September 20122012-09-26T14:28:38Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><!-- VSEBINA OD TU DALJE --></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><!-- VSEBINA OD TU DALJE --></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>Development of new technology <del class="diffchange diffchange-inline">also </del>brings the responsibility to consider its potential risks, taking into account <del class="diffchange diffchange-inline">also </del>ethical and environmental concerns arising from the rapid progress of synthetic biology. It is also our responsibility to promote the development and public acceptance of synthetic biology, which has potentials to improve the quality of life. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Development of <ins class="diffchange diffchange-inline">a </ins>new technology brings <ins class="diffchange diffchange-inline">with it </ins>the responsibility to consider its potential risks, taking into account <ins class="diffchange diffchange-inline">all the </ins>ethical and environmental concerns arising from the rapid progress of synthetic biology. It is also our responsibility to promote the development and public acceptance of synthetic biology, which has potentials to improve the quality of life. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>Among the stakeholders scientists play an important role in the social dimension of our inventions (Figure 1). Scientific assessment of new technology is a very important prerequisite before its translation into tangible applications and dissemination. As the inventors we have to examine the results from the scientific point ourselves but it will also be subjected to <del class="diffchange diffchange-inline">the </del>peer review <del class="diffchange diffchange-inline">of </del>other scientists, first at the iGEM competition and later in the form of scientific publications, which we expect will follow shortly. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Among the stakeholders<ins class="diffchange diffchange-inline">, </ins>scientists play an important role in the social dimension of our inventions (Figure 1). Scientific assessment of <ins class="diffchange diffchange-inline">any </ins>new technology is a very important prerequisite before its translation into tangible applications and <ins class="diffchange diffchange-inline">its </ins>dissemination. As the inventors we have to examine the results from the scientific point <ins class="diffchange diffchange-inline">of view </ins>ourselves but it will also be subjected to peer review <ins class="diffchange diffchange-inline">by </ins>other scientists, first at the iGEM competition and later in the form of scientific publications, which we expect will follow shortly. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><img class="inliner" src="https://static.igem.org/mediawiki/2012/d/d9/Svn12_society_scientists_fig1.jpg"/></td></tr> </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><img class="inliner" src="https://static.igem.org/mediawiki/2012/d/d9/Svn12_society_scientists_fig1.jpg"/></td></tr> </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><b>Figure 1. Presentation of the results of scientific work.</b> Anže Smole, PhD student from the National Institute of Chemistry, Ljubljana, Slovenia <del class="diffchange diffchange-inline">on </del>the meeting "Winter school - Innate Immunity and Synthetic Biology", 21.-23. 3. 2012, Pokljuka, Slovenia.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><b>Figure 1. Presentation of the results of scientific work.</b> Anže Smole, PhD student from the National Institute of Chemistry, Ljubljana, Slovenia <ins class="diffchange diffchange-inline">at </ins>the meeting "Winter school - Innate Immunity and Synthetic Biology", 21.-23. 3. 2012, Pokljuka, Slovenia.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">Therefore we </del>are including some thoughts on our project and its continuation and extension. We have already included the discussion</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">We </ins>are <ins class="diffchange diffchange-inline">therefore </ins>including some thoughts on our project and its continuation and extension. We have already included the discussion</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p><del class="diffchange diffchange-inline">Results </del>of this project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p><ins class="diffchange diffchange-inline">The results </ins>of this project clearly demonstrate the proof of principle of several new ideas, ranging from the foundational </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>advances of designing an almost limitless number of orthogonal switches to the safety mechanisms for therapy based on mammalian cells. </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Those devices could and should be further tailored for different applications. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Those devices could and should be further tailored for different applications. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>For the actual therapeutic implementation we would clearly need to prepare a stably transfected cell line with versions</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>For the actual therapeutic implementation we would clearly need to prepare a stably transfected cell line with versions</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of our proposed therapeutic device. Introduction of so many different parts into the genome will be a considerable task. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of our proposed therapeutic device. Introduction of so many different parts into the genome will be a considerable task. </p></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>We also pondered on the issue whether we should allow cells to divide inside the microcapsules or <del class="diffchange diffchange-inline">to </del>prevent the division, </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>We also pondered on the issue <ins class="diffchange diffchange-inline">of </ins>whether we should allow cells to divide inside the microcapsules or prevent the division, </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>as this may make it more difficult to exactly asses the amount of produced drug and therefore the amount of microcapsules that would need </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>as this may make it more difficult to exactly asses the amount of <ins class="diffchange diffchange-inline">the </ins>produced drug and therefore the amount of microcapsules that would need </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>to be implanted. Clearly the use of therapeutics that allow sufficiently broad range of effective therapeutic concentrations would be </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>to be implanted. Clearly the use of therapeutics that allow sufficiently broad range of effective therapeutic concentrations would be </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>preferable. For therapy of acute diseases (e.g. a myocardial infarction) where microcapsules would need to perform their task only several</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>preferable. For therapy of acute diseases (e.g. a myocardial infarction) where microcapsules would need to perform their task only <ins class="diffchange diffchange-inline">for </ins>several</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> weeks it would most likely be sufficient to have a finite amount of stably transfected, nondividing cells within the microcapsule. </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> weeks it would most likely be sufficient to have a finite amount of stably transfected, nondividing cells within the microcapsule. </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> For this purpose blocking cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> For this purpose blocking <ins class="diffchange diffchange-inline">the </ins>cell cycle might offer an advantage, since the enhanced productivity of cells with a blocked cell cycle has </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> already been reported (Fussenegger et al., 1998). </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of pro-drugs to terminate cells seems to be the safest mechanism,</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>In terms of safety mechanisms described within the project, use of pro-drugs to terminate cells seems to be the safest mechanism,</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> although it may be advantageous to select less toxic <del class="diffchange diffchange-inline">compound </del>than ganciclovir that have higher therapeutic index and as little as possible effect on host cells. We may have to increase the enzymatic activity for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and sensitization of the organism <del class="diffchange diffchange-inline">for the </del>repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in <del class="diffchange diffchange-inline">basically </del>all other applications of microencapsulated cells. </p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> although it may be advantageous to select less toxic <ins class="diffchange diffchange-inline">compounds </ins>than ganciclovir that have <ins class="diffchange diffchange-inline">a </ins>higher therapeutic index and as little as possible effect on host cells. We may have to increase the enzymatic activity <ins class="diffchange diffchange-inline">of alginate lyase </ins>for the efficient degradation of microcapsules, although production of alginate lyase may lead to production of antibodies and <ins class="diffchange diffchange-inline">a </ins>sensitization of the organism <ins class="diffchange diffchange-inline">to a </ins>repeated exposure. The alternative would be to consider leaving the microcapsules intact, which is currently the case in all other applications of microencapsulated cells. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Preclinical studies</b> on animal models will represent the real test of efficiency, long term stability and safety of therapeutic</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> cells. Our <b>pharmacokinetic model</b> <del class="diffchange diffchange-inline">will </del>prove as a valuable tool that will allow us to adjust the parameters to improve the model </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div> cells. Our <b>pharmacokinetic model</b> <ins class="diffchange diffchange-inline">should </ins>prove as a valuable tool that will allow us to adjust the parameters to improve the model </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> even further and estimate the concentration of therapeutics in different tissues on the basis of the level of therapeutics in the serum. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> even further and estimate the concentration of therapeutics in different tissues on the basis of the level of therapeutics in the serum. </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Clinical trials</b> will have to meet all medical, ethical and regulatory requirements. The first clinical trials of applications </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><b>Clinical trials</b> will have to meet all medical, ethical and regulatory requirements. The first clinical trials of applications </div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>based on synthetic biology tools are underway (Bugaj and Schaffer, 2012; devices controlling interleukin-12 production for the treatment</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>based on synthetic biology tools are <ins class="diffchange diffchange-inline">already </ins>underway (Bugaj and Schaffer, 2012; devices controlling interleukin-12 production for the treatment</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of cancer). On the 20th of July 2012 the European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> of cancer). On the 20th of July 2012 the European Medicines Agency’s Committee for Medicinal Products for Human Use has issued a positive</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> opinion that recommends the first gene therapy for approval. These reports encourage and convince us that the realization of clinical</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> opinion that recommends the first gene therapy for approval. These reports encourage and convince us that the realization of clinical</div></td></tr>
</table>Miha Jeralahttp://2012.igem.org/wiki/index.php?title=Team:Slovenia/SocietyScientists&diff=197156&oldid=prevStrazkosann at 13:25, 26 September 20122012-09-26T13:25:35Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><b>Figure 1. Presentation of the results of scientific work.</b> Anže Smole, PhD student from the National Institute of Chemistry, Ljubljana, Slovenia on the meeting "Winter school - Innate Immunity and Synthetic Biology", 21.-23. 3. 2012, Pokljuka, Slovenia.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr class="inliner"><td class="inliner"><b>Figure 1. Presentation of the results of scientific work.</b> Anže Smole, PhD student from the National Institute of Chemistry, Ljubljana, Slovenia on the meeting "Winter school - Innate Immunity and Synthetic Biology", 21.-23. 3. 2012, Pokljuka, Slovenia.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Therefore we are including some thoughts on our project and its continuation and extension. We have already included the discussion</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Therefore we are including some thoughts on our project and its continuation and extension. We have already included the discussion</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> on the advantages and drawbacks of microencapsulated cell-based therapy in the section on Implementation. </p></div></td></tr>
</table>Strazkosann