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Modeling - positive feedback loop switch

  1. Deterministic model
  2. Stochastic model
  3. C#Sim model

C#Sim model of the positive feedback loop switch

Stochastic simulation, in agreement with the deterministic analysis, proved that the positive feedback loop switch was more robust than the mutual repressor switch. It exhibited bistability without cooperativity (i.e. cooperativity equal to 1) even for leaky expression that caused the mutual repressor switch to lose bistable behavior. Higher cooperativity further increased the robustness and leaky expression tolerance, allowing for higher expression levels to be reached.

The model

Simulation results

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