Team:SJTU-BioX-Shanghai/Project/project3.2
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__NOTOC__ | __NOTOC__ | ||
+ | =Switch Modeling= | ||
+ | {{Template:12SJTU_part_summary_head}} | ||
+ | *'''State of Art''' | ||
+ | In the membrane switching system either inner or outer signals can result in a rearrangement of our protein clusters. These interactions activated by signals can change the distances between enzymes, adjust the reaction rate and then finally alter the production amount. We assume that the random diffusion distance on the membrane is about 50-100 times the distance of our cluster interaction radius, and according to PDE model the concentration deceases with radius. | ||
+ | *'''Aim''' | ||
+ | Under these basic assumptions we want to simulate the reaction progress and explain the mechanisms of redirection. | ||
+ | *'''Achievements''' | ||
- | + | Working with a chain reaction which has different path ways, after getting a signal, the system will soon recruits dissociate membrane protein parts and alters the dynamic equilibrium of products. In other words, alters the amount and ratio of our final products. | |
- | + | {{Template:12SJTU_part_summary_foot}} | |
- | + | ||
- | Working with a chain reaction which has different path ways, after getting a signal, the system will soon recruits | + | |
==Membrane Switch Model== | ==Membrane Switch Model== | ||
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In our model we assume that the reaction & substrate consumption abilities of B and C are the same. However in reality, the Km of different enzymes are not the same. Considering Michaelis-Menten equation, if the substrate concentration is 10 or more times the Km, we can ignore the effects of different abilities of enzymes, just as the normal biochemical conditions. | In our model we assume that the reaction & substrate consumption abilities of B and C are the same. However in reality, the Km of different enzymes are not the same. Considering Michaelis-Menten equation, if the substrate concentration is 10 or more times the Km, we can ignore the effects of different abilities of enzymes, just as the normal biochemical conditions. | ||
- | Amazingly our experiment results | + | Amazingly our experiment results agree with the modeling ratio, these results strongly indicates the mechanism of steering process. |
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Latest revision as of 03:29, 27 September 2012
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