http://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&feed=atom&action=historyTeam:NTU-Taida/Project/Introduction - Revision history2024-03-28T10:24:06ZRevision history for this page on the wikiMediaWiki 1.16.0http://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=292527&oldid=prevPopo: /* Introduction */2012-10-26T23:56:50Z<p><span class="autocomment">Introduction</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called '''PEPDEX''', the '''ultimate delivery system of peptides'''. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer. In our project this year, we demonstrate the PEPDEX system as a '''mind-altering bacterium''' which can deliver neuropeptide GLP-1 directly into circulation and act on the central nervous systems, modulating the eating behavior and protecting the cognitive function of brians as well. Based on the connection and interaction between '''complex adaptive biosystems''', we extend the essence of '''brain-gut-microbiota axis''' and tailor a living, communicable bacterium that mooderate and dance with human health.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"><p style="text-indent: 2em;"></ins>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called '''PEPDEX''', the '''ultimate delivery system of peptides'''. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer. In our project this year, we demonstrate the PEPDEX system as a '''mind-altering bacterium''' which can deliver neuropeptide GLP-1 directly into circulation and act on the central nervous systems, modulating the eating behavior and protecting the cognitive function of brians as well. Based on the connection and interaction between '''complex adaptive biosystems''', we extend the essence of '''brain-gut-microbiota axis''' and tailor a living, communicable bacterium that mooderate and dance with human health.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td></tr>
</table>Popohttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287465&oldid=prevShihyi: /* Introduction */2012-10-26T18:06:59Z<p><span class="autocomment">Introduction</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer. In our project this year, we demonstrate the PEPDEX system as a '''mind-altering bacterium''' which deliver neuropeptide GLP-1 directly into circulation and act on the <del class="diffchange diffchange-inline">brain</del>, modulating the eating behavior and protecting the cognitive function as well.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called <ins class="diffchange diffchange-inline">'''</ins>PEPDEX<ins class="diffchange diffchange-inline">'''</ins>, the <ins class="diffchange diffchange-inline">'''</ins>ultimate delivery system of peptides<ins class="diffchange diffchange-inline">'''</ins>. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer. In our project this year, we demonstrate the PEPDEX system as a '''mind-altering bacterium''' which <ins class="diffchange diffchange-inline">can </ins>deliver neuropeptide GLP-1 directly into circulation and act on the <ins class="diffchange diffchange-inline">central nervous systems</ins>, modulating the eating behavior and protecting the cognitive function <ins class="diffchange diffchange-inline">of brians </ins>as well<ins class="diffchange diffchange-inline">. Based on the connection and interaction between '''complex adaptive biosystems''', we extend the essence of '''brain-gut-microbiota axis''' and tailor a living, communicable bacterium that mooderate and dance with human health</ins>.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td></tr>
</table>Shihyihttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287342&oldid=prevShihyi: /* Introduction */2012-10-26T17:52:00Z<p><span class="autocomment">Introduction</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infectious diseases, and, in particular, cancer<ins class="diffchange diffchange-inline">. In our project this year, we demonstrate the PEPDEX system as a '''mind-altering bacterium''' which deliver neuropeptide GLP-1 directly into circulation and act on the brain, modulating the eating behavior and protecting the cognitive function as well</ins>.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td></tr>
</table>Shihyihttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287191&oldid=prevJasmine: /* Structure of PEPDEX */2012-10-26T17:38:07Z<p><span class="autocomment">Structure of PEPDEX</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><b>Sensor</b><br/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><b>Sensor</b><br/></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>According to different effects of peptides, modes of delivery, and ways of triggering, we can have different sensor modules. The triggering mechanisms can be <b>physical/chemical properties</b> (temperature, pH value), <b>innate biomolecules</b> (cytokines, hormones, neurotransmitters, surface antigens), or <b>external signals for artificial induction</b> (arabinose, antibiotics). The ways how these triggering factors change and interact with our sensors <del class="diffchange diffchange-inline">determines </del>the time points and reactive duration of our systems.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>According to different effects of peptides, modes of delivery, and ways of triggering, we can have different sensor modules. The triggering mechanisms can be <b>physical/chemical properties</b> (temperature, pH value), <b>innate biomolecules</b> (cytokines, hormones, neurotransmitters, surface antigens), or <b>external signals for artificial induction</b> (arabinose, antibiotics). The ways how these triggering factors change and interact with our sensors <ins class="diffchange diffchange-inline">determine </ins>the time points and reactive duration of our systems.</div></td></tr>
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</table>Jasminehttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287170&oldid=prevJasmine: /* Structure of PEPDEX */2012-10-26T17:36:24Z<p><span class="autocomment">Structure of PEPDEX</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><b>Sensor</b><br/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div> <li><b>Sensor</b><br/></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>According to different effects of peptides, modes of delivery, and ways of triggering, we can have different sensor <del class="diffchange diffchange-inline">module</del>. The triggering mechanisms can be <b>physical/chemical properties</b> (temperature, pH value), <b>innate biomolecules</b> (cytokines, hormones, neurotransmitters, surface antigens), or <b>external signals for artificial induction</b> (arabinose, antibiotics). The ways how these triggering factors change and interact with our sensors determines the time points and reactive duration of our systems.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>According to different effects of peptides, modes of delivery, and ways of triggering, we can have different sensor <ins class="diffchange diffchange-inline">modules</ins>. The triggering mechanisms can be <b>physical/chemical properties</b> (temperature, pH value), <b>innate biomolecules</b> (cytokines, hormones, neurotransmitters, surface antigens), or <b>external signals for artificial induction</b> (arabinose, antibiotics). The ways how these triggering factors change and interact with our sensors determines the time points and reactive duration of our systems.</div></td></tr>
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</table>Jasminehttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287040&oldid=prevShihyi: /* Structure of PEPDEX */2012-10-26T17:26:30Z<p><span class="autocomment">Structure of PEPDEX</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td></tr>
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</table>Shihyihttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287034&oldid=prevShihyi: /* Structure of PEPDEX */2012-10-26T17:26:10Z<p><span class="autocomment">Structure of PEPDEX</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td></tr>
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</table>Shihyihttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=287021&oldid=prevShihyi: /* Structure of PEPDEX */2012-10-26T17:25:28Z<p><span class="autocomment">Structure of PEPDEX</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Our PepdEx system consists of 5 conceptual parts, the '''sensor''', the '''effector''', the '''main circuit''', the '''stability module''', and the '''safety module'''.</div></td></tr>
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</table>Shihyihttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=286484&oldid=prevJasmine: /* Introduction */2012-10-26T16:40:57Z<p><span class="autocomment">Introduction</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against <del class="diffchange diffchange-inline">infection </del>diseases, and, in particular, cancer.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress responses. Peptides have long been widely used in pharmacology to treat certain diseases. With a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against <ins class="diffchange diffchange-inline">infectious </ins>diseases, and, in particular, cancer.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td></tr>
</table>Jasminehttp://2012.igem.org/wiki/index.php?title=Team:NTU-Taida/Project/Introduction&diff=286478&oldid=prevJasmine: /* Introduction */2012-10-26T16:40:23Z<p><span class="autocomment">Introduction</span></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Introduction==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones<del class="diffchange diffchange-inline">, </del>such as insulin, growth hormone, and ACTH<del class="diffchange diffchange-inline">, are secreted by the pituitary gland and </del>coordinate many physiological functions, including energy metabolism and stress <del class="diffchange diffchange-inline">response</del>. Peptides have long been widely used in pharmacology to treat certain diseases<del class="diffchange diffchange-inline">, and with </del>a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infection diseases, and, in particular, cancer.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>We seek to bridge the fields of synthetic biology and pharmacology to provide a revolutionary way of drug delivery called PEPDEX, the ultimate delivery system of peptides. Peptides bind to specific receptors and regulate many physiological processes. For instance, peptide-based hormones such as insulin, growth hormone, and ACTH coordinate many physiological functions, including energy metabolism and stress <ins class="diffchange diffchange-inline">responses</ins>. Peptides have long been widely used in pharmacology to treat certain diseases<ins class="diffchange diffchange-inline">. With </ins>a better understanding of diseases, peptide-based drugs can now be applied in many disease modalities (except for hormonal supply), such as neurology, and immunology. Structurally, peptide-based drugs have many benefits. First, they can be processed and modified to bind seamlessly to specific receptors with complex 3D structures, which may not be accessible to small molecule drugs. Second, when applied in immunology, synthetic peptides can be used to mimic epitopes presented to antigen-presenting cells. Modified synthetic peptides show great efficacy in the induction of cognate CD4 T-cells, which is required for therapeutic activity against infection diseases, and, in particular, cancer.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==Structure of PEPDEX==</div></td></tr>
</table>Jasmine