Team:Minnesota/Project/UV Absorption

From 2012.igem.org

(Difference between revisions)
m
Line 132: Line 132:
<div id="MainBoxContent" style="background-color:white;">
<div id="MainBoxContent" style="background-color:white;">
-
<div style="position:absolute;top:-50px;margin-left:100px; width:400px; text-align:left;">
+
<div style="position:absolute;top:-50px;margin-left:100px; width:400px; height:450px; overflow-y:scroll; text-align:left;">
<h1>UV Absorption by Skin Microbes</h1><br>
<h1>UV Absorption by Skin Microbes</h1><br>
Line 141: Line 141:
<br><br>
<br><br>
 +
 +
Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine.  Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization.  After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.
 +
 +
<br><br>
 +
Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine.  Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization.  After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.
 +
 +
<br><br>
 +
Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine.  Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization.  After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.
 +
 +
<br><br>
 +
Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine.  Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization.  After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.
 +
 +
<br><br>
 +
<a href="https://2012.igem.org/Team:Minnesota/Project">Click here to return to Projects page.</a>
<a href="https://2012.igem.org/Team:Minnesota/Project">Click here to return to Projects page.</a>

Revision as of 01:31, 4 October 2012

Team:Minnesota - Main Style Template Team:Minnesota - Template

Like us on FB and follow us on Twitter!

UV Absorption by Skin Microbes


      Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine. Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization. After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.

Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine. Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization. After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.

Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine. Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization. After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.

Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine. Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization. After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.

Between 2 and 3 million cases of nonmelanoma skin cancers arise each year, making skin cancer the most prevalent form of cancer worldwide. With skin cancer such a prominent problem worldwide, we are looking into alternative methods to protect against UV radiation. Photosynthetic organisms create an array of compounds, called mycosporine like amino acids, which naturally protect them against UV radiation. The cyanobacterium, Anabaena variabilis, contains a cluster of four genes capable of producing two UV protective compounds, mycosporine-glycine and shinorine. Utilizing BioBrick™ vector techniques, we intend to clone these genes out of A. variabilis and into Escherichia coli for characterization. After characterization and determination of the efficiency of the genes in E. coli, we will clone the shinorine gene cluster into Staphylococcus epidermidis. Successful introduction of this gene cluster and expression of UV-protective compounds could be useful as a one-time-application alternative to currently marketed sunscreens.

Click here to return to Projects page.