Team:MIT/ResultsOverview

The MIT iGEM team set out to bring aspects from the fields of DNA computing and synthetic biology together. Over the past few months we have: * established the viability of RNA as an alternative processing medium to DNA * demonstrated RNA strand displacement in vivo * designed, modeled and tested a DNA-based NOT gate * designed, modeled and tested a modular mRNA sensor, along with an inverting sensor * designed, modeled and tested various forms of regulating gene expression at the RNA level using ** miRNA-induced RNAi knockdown ** Decoy & TuD mediated double-repression systems ** self-cleaving Hammerhead ribozymes * characterized various new MammoBlock parts for transcribing short pieces of RNA in mammalian cells,