Team:Berkeley/Project/Zippers

Protein interaction domains (coiled coils, PDZ, SH3, GBD, etc) have been used by synthetic biologists to oligomerize or localize proteins. In particular, they have been applied to both scaffolding and signaling applications with impressive results. However, the limited number and diversity of well-characterized, orthogonal protein interaction domains restricts the complexity of systems that can be designed. The problem of screening for protein-protein interactions arises