Team:Colombia/Modeling/Paramterers

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Team Colombia @ 2012 iGEM

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Parameters of the equations

When we want to model a biological process, it is necessary to write the differential equation that model the system which requires a number of constants. If the real value for the constants are unknown, the system can not have any biological sense. These entries are called parameters and they are crucial elements in the mathematical model made in this project.

There are three possible sources for this parameters: i) Literature. There are a lot of studies trying to find biological parameters, such as basal rate of protein production, kinetic constants, Monod's constants, etc. Moreover, there are so many biological systems and only a few of them have been characterized. Thus, it is difficult to find the parameters that are needed. ii) we have the experimental way!!. If we make the right experiments with the biological system of interest we can know the parameters of the equations for the mathematical model. Unfortunately for the iGem project we needed the mathematical model to build the biological system so we couldn't perform experiments to know the constant of the differential equations.

Finally there is the screening of parameters. Sometimes we don't have