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From 2012.igem.org

Ethics

The ethics of synthetic biology is part of an ongoing larger debate on ethics of all biotechnologies that are emerging at the present. Human intervention with nature - It has been argued that the prospect of constructing minimal and new genomes did not violate fundamental moral precepts or boundaries, but did raise questions about the possible consequences of synthesizing new free-living organisms in relation to the concept of life and our relation to it. (Craig Venter) The definition of what is life is becoming increasingly clouded, due to the multitude of interpretations that can be applied depending on the theoretical context in which it is used. A living organism can be seen as having a number of capacities that differentiate it from inorganic matter, such as metabolism, homeostasis, capacity to grow, reproduce and, through natural selection, adapt to its environment over successive generations.

Ethical approaches to synthetic biology focus much more on consequential considerations and issues related to potential consequences from the use of synthetic biology for human beings (risk assessment and management and hazard considerations. When the uncertainties are so profound how is it possible to accurately assess potential risks?

Biosafety

In July 2002, researchers at the State University of New York announced that they had synthesized the deadly and virulent polio virus. This event, which was criticized by scientists and ethicists alike, marked the first time an organism was created entirely from off-the-shelf materials and instructions. While researchers say they did it to illustrate just how easy it is for scientists to construct life—and for would-be terrorists to construct bioweapons. Synthetic biology also represents the ability to construct artificial life forms that are not modelled on anything found in nature, and whose benefits and hazards are consequently only theoretical. There is no bioethical road map for constructing synthetic organisms one gene at a time

Bio-error

Unplanned or unexpected interactions between synthetic organisms and the environment or naturally occurring organisms produce risks to the environment and public health. At present scientists do not yet fully understand how to synthesize organisms with conventional replication and mutation properties, not only is the individual behaviour of an escaped organism difficult to foreknow and detect, its effect on the natural world is also equally impossible to foretell. In addition there is also a risk of natural genome pool contamination. It is possible that synthetic organisms could transfer genes to natural organisms. Organisms released into the environment could initiate horizontal gene transfer and affect the biotic balance of an ecosystem, or evolve past their original function to elicit unexpected side effects.

Biosecurity

Ethical issues arise particularly from the dangers of using synthetic lethal and virulent pathogens for terrorist attacks or bio war. Bio weapons such as modified pathogenic viruses or bacteria as well as synthetic organisms that have been engineered to produce toxins. As the ability to carry out DNA synthesis is no longer confined to elite scientists, rather anyone with a laptop can access public DNA sequence databases and DNA design software. Thus issues related to the freedom of science and censorship emerge, including the process of censorship decision-making applicable to the publishing of scientific results that may have a use for virulent pathogenic product production