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Team:Paris-Saclay/Project
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Overall project
The iGEM Paris-Saclay team has started to develop two projects this year.
For the first project, we are trying to create a bacteria capable of informing scientists about the current environmental conditions. For example, when the temperature drops or increases in excess, the bacteria would produce a colored compound. To obtain this result, we will use RNA thermometers, which are molecules that are capable of changing their conformation depending on the temperature. This allows us to regulate the synthesis of certain proteins. If the temperature sensing system works well, we want to create similar systems with different colors for other parameters, such as pH or oxygenation. The goal of this project would be to obtain a strain capable of telling an experimentalist if the cultures standard conditions were not met and therefore monitor the smooth running of an experiment.
The second project consists in developping a bacterian photographic film. This would be done by using proteins called rhodopsins, which can be activated with a specific electromagnetic wave. After mutagenesis of these proteins, we will try to obtain rhodopsins capable of being activated at different lenghtwaves. Then we will attempt to link this system to the production of fluorescent proteins of different colors. Ultimately, the system will be able to reproduce an image on a bacterian film, thanks to rhodopsins activated at different wavelengths.
We will keep you informed on the status of our two projects !
