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The Grenoble iGEM team intends to build an ultra sensitive detector. The goal is to produce a detector that can hugely amplify a given signal. It consists of three modules:
- 1. the first gets the signal
- 2. the second amplifies it
- 3. the third sends the output
The detection module is a membrane receptor that once activated by a chemical compound actuates an amplification loop. The loop enhances the cell response efficiency.
The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs.
Once amplified and filtered the signal is transmitted to the neighboring bacteria.
In this way a noticeable fluorescent emission is generated.
Scheme of the concept
