Team:Nanjing China Bio/future

In our experiment of A, we use the background information that the amino acid glucose and other nutrition inside the tumors are much higher than those in normal tissues. We knocked out the gene which encoding arginine of VNP, expecting that after the targeting, the VNP will mostly exist inside the tumor, where the nutrition is the highest. In the future, we will introducing this kind of VNP into the rats with melanoma, to see whether our designed VNP can really work on the prolonging of the rat with cancer.

In our experiment of B, we got some anaerobic promoter, which will improve the bacteria's ability of targeting inside the oxygen-poor cells and tissues including the tumor, where the quantity of oxygen is much lower than the common tissues. In other words, it provides us with a new future direction of cancer therapy ------we can introduce the efficient anaerobic promoter into VNP, which will target inside the tumors and decrease the side-effect of the VNP to the lowest. In order to prove our assumption, we will have our experiments of introducing the VNP with the promoter we designed into the rats with melanoma, in order to see whether the lifetime of them can prolong with the help of our designed promoter. We hope it can really work!