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Team:Grenoble/Human Practice/BSS
From 2012.igem.org
Design & evaluation of the BioBrick Safety Sheets (BSS) design of the BSS:
Synthetic biology is a new and emerging discipline with a lot of potential but also with an important part of risk. But unlike other disciplines such as chemistry there is no standard and reliable way of assessing risk! Where does every component of our Biobrick come from? What was its initial function in nature? Should we fear a particular interaction with another component? Has a particular mutation been observed? These are the question that each biologist has asked himself at least once but couldn’t find an answer because it’s too complicated and exhausting! To release your pain the Grenoble Team has found a solution: What about a new reliable and universal way of storing all these information and including them in the registry part? Thus every team and every biologist would be able to have access to these information and even add his own observations and experimental results to enlarge the database. To sum up, the Biobrick Safety Sheet includes mainly two sections:- A section where we specify the biobrick , the origin and the initial function of each component in nature (promoter, rbs, coding sequence…)
- A section that lists: the random interactions we encountered during the construction, the results of at least one experiment that considers the environment in which the biobrick will evolve and other experiments we think it’s important to consider in order to assess the biobrick risk level.
Other teams opinion about BSS:
As we want the BSS structure to be clear and concise. We tried early to contact as many iGEM teams as possible from all over the world in order to have feedbacks about the idea and the possible improvements for the BSS. For this purpose we used matchmaker [click here] by posting a request. We’ve also sent an e-mail to all the European teams. You can find below the list of the teams that consented to give feedbacks.
