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Our part of the collaboration with RHiT was helping them with stochastic modelling of the trigger system for mating in yeast. The full mechanism has been quite well studied, but it is very complicated[http://dx.doi.org/10.1002/yea.1122]. In RHiTs model, the final steps of the mechanism is activation of the Ste12 protein by Fus3. To simplify the model, production of Fus3 in the model was described by a sigmoid curvefound in experiments[http://dx.doi.org/10.1038/nature08946]. Inactive Ste12 was quickly activated by the presence of Fus3, so the outcome of active Ste12 followed a similar sigmoid curve, giving the expected switch behaviour.
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