Antibody module: In the first step an antibody gene is integrated into the genome.
Antibody module: The CHO-cell produces the antibody and presents it on the cell surface.
Mutation module: The Enzyme AID mutates the antibody gene -> maturation
Selection Module: A virus infects cells with the “right” antibody. Those cells survive.
The „right“ cells are switched to antibody secreting cells with Cre-recombinase.