Our designed BioBricks containing the gene for the mature region of mouse Bone Morphogenetic Protein 2 (BMP2) all possess a level of risk. As a mammalian biochemical agent, it is known to elicit a wide variety of biological effect on human tissue organs, of which the most well known are bone and cardiac cell differentiation induction. However, as a defining member of the Transforming Growth Factor Beta (TGF-β) pathway, it also plays important roles in cell proliferation. Thus, induction of excess (or otherwise external) BMP2 may lead to undesirable tissue behavior in mammalian systems.