Team:Goettingen/Project

From 2012.igem.org

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<h2><b>Welcome to iGEM Göttingen</b></h2>
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<p align="justify" style="line-height:1.6em">
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iGEM is a international competition hosted by the MIT in Boston, USA, for undergraduate students
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of disciplines related to molecular biology. iGEM stands for International Genetically Engineered
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Machine competition. One the one hand, it targets to combine aspects of education and social
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collaboration among undergraduate students, on the other hand, it provides a library for
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standardized and interchangeable parts which can be used in living systems, particularly
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in model organisms like E. coli. Student groups from all over the world will receive a
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requested kit of biological parts, also called "biobricks", and work over the summer on
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an individual research project. Every year, the "Registry of Standard Biological Parts"
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is upgraded with further biobricks by the participating iGEM teams. These biobricks will
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be accessible to the iGEM community in the following years in order to use these parts for
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their own projects.  <br>
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<br>
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The iGEM competition started in 2003 as a course for students of the MIT only. 2011,
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already 165 universities from all over the world competed against each other. This year,
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it is the first participation of University of Goettingen, Germany. The iGEM competition
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is a great opportunity for students to gain and improve a multitude of skills that are
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necessary during a carrier as a molecular biologist. Such skills would be planning and
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organizing a project, including fund raising and team recruitment, coordination of lab
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work, designing experiments and working together as a team. Next to intensive lab work
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during the summer, also literature search and well-structured documentation of the
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experiments is crucial.<br>
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</p>
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<br>
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<h2><b>Homing Coli</b></h2>
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<i>Escherichia coli</i> is a commonly used bacterial model organism. It has lots of beneficial
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traits like a short generation time and it can be easily manipulated. Most <i>E. coli</i>
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strains that are used in laboratories do not exhibit high motility. The crucial element for
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motility is the flagellum, which is rotated by a molecular motor within the cell wall.
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Consequently, these are reduced in cultivated <i>E. coli</i> strains.<br>
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<br>
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Our goal is to create an <i>E. coli</i> strain with increased swarming motility on special
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agar plates. Therefore, we will perform directed mutagenesis techniques of motile <i>E. coli</i>
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and enhance their swarming ability. The fastest <i>E. coli</i> strains will be selected and
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further improved. At the same time we will then be able to create an effective motility-selection
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  method.        <br>
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<br>
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Now, you are probably wondering what the advantage of a fast<i> E. coli</i> might be. The
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beneficial fast phenotype can be combined with the ability of this bacterium to sense
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specific compounds in their environments. Chemo-receptors enable it to move towards
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or along gradients of such substances. The combination of speed and chemotaxis allows
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us to identify <i>E. coli</i> strains, which can find interesting compounds. Thereby, an
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easy method for the detection of pollutants, toxins or even tumors could be provided.<br><br>
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<img width="400 px" src="http://www.patrickreinke.de/igem/homingcoli.jpg">
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</p>
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<br>
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<h2><b>Synthetic Biology</b></h2>
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<p align="justify" style="line-height:1.6em">
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Synthetic biology is an interdisciplinary scientific area that has recently developed.
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It links various fields of science like biology, chemistry, physics, molecular genetics,
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informatics and engineering.<br>
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<br>
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Due to this combination the relation of biological design and function can be investigated
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from an entirely new perspective. The previous approach was limited to the examination of
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a structure and its function and the attempt to explain how they correlate.
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Recently, the reverse strategy is applied. Biological parts are specifically designed and
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constructed according to a desired function. These parts are characterized by a standardized
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modular design that facilitates their handling. The subsequent introduction of the synthetic
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constructs to living cells can either cause the replacement of original cellular components
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or result in additional elements that act cooperatively or more or less autonomously.<br>
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<br>
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<img src="http://www.patrickreinke.de/igem/synbio.jpg">
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<br>
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Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated
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Gene Circuits. SCIENCE, Vol. 333: 1244-1248.<br>
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<br>
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Another very important and necessary feature of biological parts is orthogonality,
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which means in this context that independent devices can be combined unrestrictedly.
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  This principle derives from the area of engineering and aims to alter subsystems,
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  without impeding others.<br>
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<br>
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This way cells can be modified as requested, resulting in a predictable behaviour.
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Among others, this technique can be beneficial for the effective production of
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certain substances, like biofuels or antibiotics.
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</p>
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<br>
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<br>
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<table bordercolor="black" border="1 px" width="600 px"><tr><td>
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<b>Important pages</b>:<br>
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<a href="https://2012.igem.org/Team:Goettingen">Home</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Team">Team</a>;
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<a href="https://igem.org/Team.cgi?year=2012">Official Team Profile</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Project">Project</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Parts">Parts submitted to the Registry</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Modeling">Modeling</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Notebook">Notebook</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Saftey">Saftey</a>;
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<a href="https://2012.igem.org/Team:Goettingen/Attributions">Attributions</a>
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</td></tr>
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</table>
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</font>
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                                <!-- Text body zu Ende -->
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                                <!-- News body anfang -->
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<p>
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</p>
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<embed src="http://www.patrickreinke.de/igem/motionflashcoli.swf" type="application/x-shockwave-flash" pluginspage="http://www.macromedia.com/go/getflashplayer" wmode="transparent" height="180" width="240">
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<font face="Verdana" size="-1">Explore our Project with Flash Coli
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<a href="https://2012.igem.org/Team:Goettingen/Flashcoli">Click here</a>
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<br><hr>
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<p>
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</p><p>
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</p>
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<!-- News cap -->
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<h2> <span><b>News</b></span></h2>
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        <!-- News 1 --> <br>
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<p align="left"><i>04 May 2012,</i>  <b>KWS SAAT AG is now headsponsor</b>
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</p>
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<div><div><span><a href="https://2012.igem.org/Image:Igem_hd_pic.JPG" class="image"></a></span></div></div>
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<p align="left">
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The IGEM-Göttingen Team is happy to welcome the <a href="http://www.kws.de/">KWS SAAT AG</a> as head sponsor!
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For more informations click <a href="https://2012.igem.org/Team:Goettingen/Sponsors" title="Team:Goettingen/Sponsors">
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here</a>.
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<center><img width="150 px" src="http://www.patrickreinke.de/igem/kws.png"></center>
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        <!-- News 1 end-->
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<br><hr>
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        <!-- News 2 -->  <br>
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</p><p><i>04 April. 2012,</i>    <b> Sartorius AG is now Sponsor</b>
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</p>
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<p>
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</p><p>The first sponsor of our IGEM Team is the company <a href="http://www.sartorius.com">Sartorius AG</a>. More informations about our
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sponsors are <a href="https://2012.igem.org/Team:Goettingen/Sponsors" title="Team:Goettingen/Sponsors">
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here</a>..
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<center><img width="250 px" src="http://www.patrickreinke.de/igem/sartorius.png"></center>
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        <!-- News 2 end-->
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<br>
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<br>
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<!-- News sponsor -->
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<hr><h2> <span><b>Sponsors</b></span></h2>
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<a href="http://www.kws.com"><center><img width="150 px" src="http://www.patrickreinke.de/igem/kws.png"></center></a> <br><br>
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<br>
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<a href="http://www.sartorius.com"><center><img width="250 px" src="http://www.patrickreinke.de/igem/sartorius.png"></center></a>
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<hr><!-- News sponsor end -->
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Revision as of 15:22, 15 July 2012

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