Team:NRP-UEA-Norwich

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Revision as of 15:31, 13 July 2012

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File:NRP-UEA-Norwich logo.png

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NRP UEA iGEM Team 2012 Project Outline

The iGEM 2012 team for the Norwich Research Park and University of East Anglia (NRP UEA) are a group of seven biology-based undergraduate students working in the labs within UEA’s BIO building. We have been looking at the role of nitric oxide (NO) in biological systems and are aiming to produce a BioBrick that can sense NO within an environment, report on the levels, and go on to make relevant and desirable changes.

Possible applications we see for this include; cancer therapeutics, where NO levels are detected and raised above the level at which it aids angiogenesis and into the levels at which it is toxic to a tumour; and environmental aspects, where the bio-sensor may be attached to bioluminescence in order to report levels of NO in soil for instance.

Our first BioBrick will be a hybrid bacterial and mammalian promoter (using PYEAR and NS2E9 elements) which will detect NO levels. We aim to use a chassis of E. coli in order to test our BioBrick before investigating its competency within a Salmonella chassis for future applications within a medical system. We also aim to characterise BioBricks produced by previous iGEM teams, especially those involved with sensing physiologically-relevant molecules and reporting with fluorescence or bioluminescence.

We have also looked at various aspects of human outreach and plan to undertake a programme of Synthetic Biology public awareness as well as employing various methods to make our project accessible to those interested outside of the team.

File:NRP-UEA-Norwich team.png

Your team picture

Team NRP-UEA-Norwich

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-|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
 |[[Image:NRP-UEA-Norwich_logo.png|200px|right|frame]]
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-''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+'''NRP UEA iGEM Team 2012 Project Outline'''
+The iGEM 2012 team for the Norwich Research Park and University of East Anglia (NRP UEA) are a group of seven biology-based undergraduate students working in the labs within UEA’s BIO building. We have been looking at the role of nitric oxide (NO) in biological systems and are aiming to produce a BioBrick that can sense NO within an environment, report on the levels, and go on to make relevant and desirable changes.
+Possible applications we see for this include; cancer therapeutics, where NO levels are detected and raised above the level at which it aids angiogenesis and into the levels at which it is toxic to a tumour; and environmental aspects, where the bio-sensor may be attached to bioluminescence in order to report levels of NO in soil for instance.
+Our first BioBrick will be a hybrid bacterial and mammalian promoter (using PYEAR and NS2E9 elements) which will detect NO levels. We aim to use a chassis of E. coli in order to test our BioBrick before investigating its competency within a Salmonella chassis for future applications within a medical system. We also aim to characterise BioBricks produced by previous iGEM teams, especially those involved with sensing physiologically-relevant molecules and reporting with fluorescence or bioluminescence.
+We have also looked at various aspects of human outreach and plan to undertake a programme of Synthetic Biology public awareness as well as employing various methods to make our project accessible to those interested outside of the team.
 |[[Image:NRP-UEA-Norwich_team.png|right|frame|Your team picture]]
 |-