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Team:Leicester
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Over the summer the team intends to find and extract the genes involved in the pathway of degrading Expanded Polystyrene (EPS). This can then be used to develop an improved pathway, involving modifications to the enzymes that act on polystyrene, and the existing enzymes able to degrade aromatic and aliphatic hydrocarbons to fit polystyrene and its derivatives into the active sites. The bacteria strain that has these new genes inserted should then be able to degrade polystyrene at a higher rate than natural bacteria. | Over the summer the team intends to find and extract the genes involved in the pathway of degrading Expanded Polystyrene (EPS). This can then be used to develop an improved pathway, involving modifications to the enzymes that act on polystyrene, and the existing enzymes able to degrade aromatic and aliphatic hydrocarbons to fit polystyrene and its derivatives into the active sites. The bacteria strain that has these new genes inserted should then be able to degrade polystyrene at a higher rate than natural bacteria. | ||
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| + | We also intend to model several enzymes and mutate them to accept polystyrene and other intermediates in the pathway more readily into their active site, to potentially create a new pathway to at the very least make the polystyrene soluble. | ||
This new strain that can degrade the polystyrene could then potentially be applied to landfill sites to degrade the polystyrene reducing the amount of long-lasting waste and saving the ground from long-term pollution, as well as being used by companies to stop polystyrene from being put into landfill sites in the future. | This new strain that can degrade the polystyrene could then potentially be applied to landfill sites to degrade the polystyrene reducing the amount of long-lasting waste and saving the ground from long-term pollution, as well as being used by companies to stop polystyrene from being put into landfill sites in the future. | ||
Revision as of 12:14, 13 July 2012
| The team consists of a computer scientist, 2 organic chemists, 3 genetecists, and 3 biochemists. The whole team has been insured by the genetics department to work in the lab so all of us can contribute to the actual experiments.
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Our project is about trying to reduce the waste going into landfill sites by engineering a bacteria to degrade polystyrene. Some bacteria have been found to form biofilms on polystyrene, indicating that polystyrene may be being degraded, albeit at a very slow rate. We have several different parts to our project, including a citizen science experiment (CSE). Over the summer the team intends to find and extract the genes involved in the pathway of degrading Expanded Polystyrene (EPS). This can then be used to develop an improved pathway, involving modifications to the enzymes that act on polystyrene, and the existing enzymes able to degrade aromatic and aliphatic hydrocarbons to fit polystyrene and its derivatives into the active sites. The bacteria strain that has these new genes inserted should then be able to degrade polystyrene at a higher rate than natural bacteria. We also intend to model several enzymes and mutate them to accept polystyrene and other intermediates in the pathway more readily into their active site, to potentially create a new pathway to at the very least make the polystyrene soluble. This new strain that can degrade the polystyrene could then potentially be applied to landfill sites to degrade the polystyrene reducing the amount of long-lasting waste and saving the ground from long-term pollution, as well as being used by companies to stop polystyrene from being put into landfill sites in the future. |  From left to right: Will Harrison, Nathan Hanna, Anthony Cox, Chris Morton, Luke Thompson, Grace Hodson, Neil Nathwani, Sir Alec Jeffreys, Philip Higgs. |
| Photo with Sir Alec Jeffreys |
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