Team:Amsterdam/practices/results
From 2012.igem.org
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We tried to further investigate the future potential of our system as a multi-sensor that could register different signals in the environment. In the light of this, we consulted BioDetection Systems b.v. (BDS). We spoke with dr. Bart van der Burg, Chief Scientific Officer at BDS b.v. | We tried to further investigate the future potential of our system as a multi-sensor that could register different signals in the environment. In the light of this, we consulted BioDetection Systems b.v. (BDS). We spoke with dr. Bart van der Burg, Chief Scientific Officer at BDS b.v. | ||
- | '''Bioassays''' | + | '''Bioassays'''<br\> |
BDS uses human and animal cells to detect compounds in samples, as a cheaper alternative to existing chemical screening methods. This is done by measuring the acute toxic effects of the compound on the cell instead of directly measuring the presence of the compound. Measured substances are: (I) aromatic carbon-hydroxides (dioxins) and (II) hormones. Dioxins are very stable and not metabolized by the cells that measure their toxic effects, hence easily measurable | BDS uses human and animal cells to detect compounds in samples, as a cheaper alternative to existing chemical screening methods. This is done by measuring the acute toxic effects of the compound on the cell instead of directly measuring the presence of the compound. Measured substances are: (I) aromatic carbon-hydroxides (dioxins) and (II) hormones. Dioxins are very stable and not metabolized by the cells that measure their toxic effects, hence easily measurable | ||
using this technique. Hormones are sometimes metabolized by the chassis cells used, which affects the outcome of the measurement. European and international legislation concerning analytical chemistry is mostly directed at chemical measurements of dioxins, not the biological measurement. | using this technique. Hormones are sometimes metabolized by the chassis cells used, which affects the outcome of the measurement. European and international legislation concerning analytical chemistry is mostly directed at chemical measurements of dioxins, not the biological measurement. | ||
- | '''Cons to bioassays''' | + | '''Cons to bioassays'''<br\> |
Mass spectrometry methods are much more widely used in the field and more familiar to companies looking for detection systems. This technique allows to measure various chemicals simultaneously, this technique is very expensive. Mass spectrometry methods are also not completely unambiguous either. For our product to be a viable and interesting measurement method, it has to be much easier and cheaper than already known chemical analytical methods. | Mass spectrometry methods are much more widely used in the field and more familiar to companies looking for detection systems. This technique allows to measure various chemicals simultaneously, this technique is very expensive. Mass spectrometry methods are also not completely unambiguous either. For our product to be a viable and interesting measurement method, it has to be much easier and cheaper than already known chemical analytical methods. | ||
- | '''View on applications''' | + | '''View on applications'''<br\> |
We summarized the molecular mechanism of the Cellular Logbook for Bart van der Burg and asked him if he could see advantages of a memory module in a multi-sensor system. Applications he could think of on the spot: | We summarized the molecular mechanism of the Cellular Logbook for Bart van der Burg and asked him if he could see advantages of a memory module in a multi-sensor system. Applications he could think of on the spot: | ||
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* Control of compound emission at industrial sites (e.g. factory): he envisioned to place the bacteria at multiple locations around a factory site to get an idea where and when chemicals were released. | * Control of compound emission at industrial sites (e.g. factory): he envisioned to place the bacteria at multiple locations around a factory site to get an idea where and when chemicals were released. | ||
- | '''Problems envisioned''' | + | '''Problems envisioned'''<br\> |
* Release of GMOs into the environment | * Release of GMOs into the environment |
Revision as of 00:48, 27 September 2012