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Revision as of 21:22, 26 September 2012
Antibody module: In the first step, an antibody gene is integrated into the genome of CHO cells.
Antibody module: The CHO cell expresses the antibody on the cell surface.
Mutation module: The enzyme AID mutates the antibody gene -> maturation
Selection Module: A virus infects cells with high affine antibodies. These cells survive.
The selected cells are switched to antibody secreting cells with Cre-recombinase.
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