Team:Trieste

From 2012.igem.org

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<h2>We present you the Jolly JoCare</h2>
<h2>We present you the Jolly JoCare</h2>
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<a href="https://2012.igem.org/Team:Trieste/project/overview"target="_blank">Overview </a> -
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<strong>Background</strong><br/>Recent studies have evidenced that having a beneficial and healthy
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<strong>Background</strong><br/>Recent studies have evidenced that having a beneficial and healthy  
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intestinal microflora is very important for human health.<br/>
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                intestinal microflora is very important for human health.<br/>
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                                 <strong>Project</strong><br/>
                                 <strong>Project</strong><br/>
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                                Our
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aim is to modify a bacteria normally found in human gut and
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create a safe, controllable and versatile molecular platform
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which can be used to produce a wide range of molecules leading
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to a beneficial probiotic. For this purpose we have chosen the
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E. coli strain Nissle 1917 which has been used for many years as
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a probiotic. We designed a robust gene guard system regulated
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by a novel and easy to control inducible cumate switch that
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activates the production of a human antimicrobial peptide LL-37
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that can kill the bacteria and also avoid horizontal transfer.
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    <strong>Applications</strong><br/>The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.  
    <strong>Applications</strong><br/>The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.  

Revision as of 17:41, 26 September 2012

Our Project

Quick Links

The Team

We present you the Jolly JoCare


Overview -

Background
Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health.

Project

Applications
The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.

Achievements
Quick link to our judging form and Achievements summary
a
Project
Overview - Have a look to our Jolly JoCare Project at a glance!
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Data
Click here to reach our summary page
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Team iGEM 2012

Contact us

For other information, write to:

igem2012@gmail.com
Università degli studi di Trieste ICGEB Illy Fondazione Cassa di Risparmio
iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012
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