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Team:Nanjing China Bio/index
From 2012.igem.org
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<i>Salmonella typhimurium</i> VNP20009 (VNP) has unique characteristics of high tumor targeting and low toxicity. It can highly colonize central parts of tumor tissues. Our project aims to decrease the influence of the bacteria on normal tissues by enhancing the bacteria's ability of tumor targeting through modifying the amino acid metabolism pathways. We also use VNP as a vector to express exogenous genes with anaerobic promoters in the upper stream to further improve the effect of tumor targeting. Thus, the bacteria could be used as an efficient method of tumor treatment. | <i>Salmonella typhimurium</i> VNP20009 (VNP) has unique characteristics of high tumor targeting and low toxicity. It can highly colonize central parts of tumor tissues. Our project aims to decrease the influence of the bacteria on normal tissues by enhancing the bacteria's ability of tumor targeting through modifying the amino acid metabolism pathways. We also use VNP as a vector to express exogenous genes with anaerobic promoters in the upper stream to further improve the effect of tumor targeting. Thus, the bacteria could be used as an efficient method of tumor treatment. | ||
Revision as of 16:53, 26 September 2012
Salmonella selection
Salmonella typhimurium VNP20009 (VNP) has unique characteristics of high tumor targeting and low toxicity. It can highly colonize central parts of tumor tissues. Our project aims to decrease the influence of the bacteria on normal tissues by enhancing the bacteria's ability of tumor targeting through modifying the amino acid metabolism pathways. We also use VNP as a vector to express exogenous genes with anaerobic promoters in the upper stream to further improve the effect of tumor targeting. Thus, the bacteria could be used as an efficient method of tumor treatment.
...learn more>>
Tumor-Targeted: tumor-targeting provides a high-performance manner in which we can treat cancer more accurately.
Salmonella: a kind of harmful bacterium may be the light to a harmful disease.
Anaerobic promoter: it can lead to the expression of some antitumor agents directly inside the tumor.
Kongfu-bacteria: the bacteria we designed is just like a Kongfu-panda,using its terrific "Kongfu" to kill tumors.
Auxotrophy：the inability of the Salmonella to synthesize a particular organic compound required for its growth.
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Xiao-Xin Zhang
Xiao-Xin Zhang is currently a doctor -
Hong-Qin Zhuang
Hongqin Zhuang, Ph.D., associate -
jiahuang Li
jiahuang Li, Ph.D. received Doctor's Degree -
Min Lu
Min Lu, born in December, 1965, graduated -
Zichun Hua
Zichun Hua, Ph.D. Changjiang Scholar -
An Hu
Zichun Hua, Ph.D. Changjiang Scholar
Our team consists of senior and junior students from departments of Life Science, Computer
Science and Journalism and Communication. We come together and work together for one common
goal. Though there were difficulties and obstacles during the process, we didn't give up and
gave all our efforts. Thanks to iGEM for giving us a chance for us to meet each other and
work together and we will do our best.
5.12(all)
This is our first regular meeting since we formed our iGEM team. During this meeting, we introduced ourselves to each other, and learned more about our goal. Our team consists of sophomore and junior students from different departments.
The first section was given by Kevin about the general background of iGEM and the specific requirements of the competition. The techniques that could be used in our experiments were also introduced, and it's lucky to know that we have already learned the fundamental knowledge of these techniques.
The first section was given by Kevin about the general background of iGEM and the specific requirements of the competition. The techniques that could be used in our experiments were also introduced, and it's lucky to know that we have already learned the fundamental knowledge of these techniques.
