Team:SJTU-BioX-Shanghai/Project
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- | One of our devices, called ''Membrane Accelerator'', functions by localizing enzymes to membrane surface. ''E.coli'' inner membrane serves as a two-dimensional plane that can accommodate different protein assemblies linked with enzymes. Otherwise diffusing enzymes can form clusters on membrane through interacting protein domains and ligands. Enzyme clusters help substrates flow between enzymes, and thus increase yields of sequential biological reactions. | + | One of our devices, called ''Membrane Accelerator'', functions by localizing enzymes to membrane surface. ''E.coli'' inner membrane serves as a two-dimensional plane that can accommodate different protein assemblies linked with enzymes. Otherwise diffusing enzymes can form clusters on membrane through interacting protein domains and ligands. Enzyme clusters help substrates flow between enzymes, and thus increase yields of sequential biological reactions. |
- | As some work has been done in reaction acceleration, people failed to control those reactions artificially and dynamically during biosynthetic process.''Membrane Rudder'' device, however, offers a novel method to control the direction of reactions through light and chemical signals. More strikingly, we further combine ''Membrane Rudder'' system with genetic circuits by recruiting RNA aptamer and its corresponding binding protein. Thus both extracellular and intracellular signal would trigger the subsequent reaction. | + | As some work has been done in reaction acceleration, people failed to control those reactions artificially and dynamically during biosynthetic process.''Membrane Rudder'' device, however, offers a novel method to control the direction of reactions through light and chemical signals. More strikingly, we further combine ''Membrane Rudder'' system with genetic circuits by recruiting RNA aptamer and its corresponding binding protein. Thus both extracellular and intracellular signal would trigger the subsequent reaction. |
===Why MEMBRANE?=== | ===Why MEMBRANE?=== |
Revision as of 12:49, 26 September 2012
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