Team:SYSU-China/project/manufactureapplications

New Fermentation Method

In microbial fermentation industry, the most important device is fermentation tank. It contains engineering bacteria for fermenting, then we can get the products we want. There has a computer monitoring system to monitor and control the bacteria density and their living conditions, such as temperature, humidity, air pressure and so on. And this system needs to add new bacteria from a device into the fermentation tank constantly to maintain a equilibrium statement, we can call this device reproduction tank or incubator tank. But this traditional balance faces two significant problems:

1. The energy utilization ratio is not very high ----No matter in fermentation tank (a significant parts) or incubator tank (a very small part, scarely any sometimes), the energy will be used both for reproduction and metabolism (the product we want and some other metabolins).
2. 2. Products are not pure---- There are different metobolins mix together, and the intermediate products of reproduction will exit,too. and end product mutual mixed existence. It is difficult to separate and increase the cost of purification.

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If we use the “ CLICK switch“ engineering bacteria in fermentation process， then we can realize simplification metabolic statement / breeding state --- breaking the balance, obtain some special advantages.

1. More energy can be used for metabolin producing. This “CLICK switch” mechanism is able to enhance the ratio of input and output, namely it can produce more needed metabolites each unit energy consumption, then energy saved.
2. Fermentation tank does not exist reproducing state of bacteria, so there are no breeding intermediate products. Finally we get pure metabolites need to improve product purity, save or simplified separation and purification steps, save money.
3. In traditional fermentation, the strains in incubator tank should keep in a lower density, so the bacteria can get a higher reproductive rate. But these “ CLICK switch”(超链接) engineering bacteria doesn`t have this restriction, which means we can replenish more quickly。