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Team:Trieste
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<strong>Background</strong></br>Recent studies have evidenced that having a beneficial and healthy | <strong>Background</strong></br>Recent studies have evidenced that having a beneficial and healthy | ||
| - | intestinal microflora is very important for human health.< | + | intestinal microflora is very important for human health.<br/> |
| - | + | <br/> | |
| - | <strong>Project</strong>< | + | <strong>Project</strong><br/> |
Our | Our | ||
aim is to modify a bacteria normally found in human gut and | aim is to modify a bacteria normally found in human gut and | ||
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activates the production of a human antimicrobial peptide LL-37 | activates the production of a human antimicrobial peptide LL-37 | ||
that can kill the bacteria and also avoid horizontal transfer. | that can kill the bacteria and also avoid horizontal transfer. | ||
| - | < | + | <br/> |
| - | < | + | <br/> |
<strong>Applications</strong></br>The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus. | <strong>Applications</strong></br>The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus. | ||
</p> | </p> | ||
Revision as of 18:00, 25 September 2012
Our Project
Quick Links
The Team
We present you the Jolly JoCare
BackgroundRecent studies have evidenced that having a beneficial and healthy
intestinal microflora is very important for human health.
Project
Our
aim is to modify a bacteria normally found in human gut and
create a safe, controllable and versatile molecular platform
which can be used to produce a wide range of molecules leading
to a beneficial probiotic. For this purpose we have chosen the
E. coli strain Nissle 1917 which has been used for many years as
a probiotic. We designed a robust gene guard system regulated
by a novel and easy to control inducible cumate switch that
activates the production of a human antimicrobial peptide LL-37
that can kill the bacteria and also avoid horizontal transfer.
ApplicationsThe safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.
