|
|
| Line 16: |
Line 16: |
| | </head> | | </head> |
| | | | |
| - | <body>
| |
| - |
| |
| - | <div class ="header_uofl">
| |
| | <img id="logo" src="https://static.igem.org/mediawiki/igem.org/f/f6/Comp%C3%A9tition_1.jpg" height="400" width="100%"> | | <img id="logo" src="https://static.igem.org/mediawiki/igem.org/f/f6/Comp%C3%A9tition_1.jpg" height="400" width="100%"> |
| - | </div> | + | </html> |
| | | | |
| | + | {| style="color:#1b2c8a;background-color:#fff;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="100%" align="center" |
| | + | !align="center"|[[Team:ULB-Brussels|Home]] |
| | + | !align="center"|[[Team:ULB-Brussels/Team|Team]] |
| | + | !align="center"|[https://igem.org/Team.cgi?year=2012&team_name=ULB-Brussels Official Team Profile] |
| | + | !align="center"|[[Team:ULB-Brussels/Project|Project]] |
| | + | !align="center"|[[Team:ULB-Brussels/Parts|Parts Submitted to the Registry]] |
| | + | !align="center"|[[Team:ULB-Brussels/Modeling|Modeling]] |
| | + | !align="center"|[[Team:ULB-Brussels/Notebook|Notebook]] |
| | + | !align="center"|[[Team:ULB-Brussels/Safety|Safety]] |
| | + | !align="center"|[[Team:ULB-Brussels/Attributions|Attributions]] |
| | + | |} |
| | | | |
| | + | |
| | + | <html xmlns="http://www.w3.org/1999/xhtml" lang="en"> |
| | | | |
| - |
| |
| - | <div class="header_uofl_nav">
| |
| - | <ul class="header_uofl_nav">
| |
| - |
| |
| - |
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels"></a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Team"> Our Team </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Project"> The Project </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Parts"> Parts submitted </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Notebook"> Notebook </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Safety"> Safety </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Attributions"> Attributions </a></li>
| |
| - | <li><a href="https://2012.igem.org/Team:ULB-Brussels/Previous"> Older wikis </a></li>
| |
| - |
| |
| - | </div>
| |
| - |
| |
| - | <div class ="content_uofl">
| |
| - | <div class="intro_wrap">
| |
| | | | |
| | | | |
| | | | |
| - | <font color=#1D702D;background-color:#FC7F3C;><font Size="100"><p> Team ULB-Brussels, welcome to our wiki! </p></font> | + | <center><font color=#1D702D;background-color:#FC7F3C;><font Size="100"><p> Team ULB-Brussels, welcome to our wiki! </p></font></ center> |
| - | <h2>Abstract of our project</h2>
| + | |
| | | | |
| - | <div class="section_intro_side"> | + | <font color=black> |
| | | | |
| - | <p>In synthetic biology, one of the main issues scientists and engineers must tackle is biochemical pathways optimization.
| |
| - | In fact, it is often difficult to predict in which positions the genes of the pathway must be assembled in order to efficiently
| |
| - | produce the desired molecule.
| |
| - | <br></br>
| |
| - | In this project, we are going to develop an exceptional natural tool that could be used to optimize bio-production pathways:
| |
| - | the integron. Integrons are genetic platforms which contain (re)movable gene cassettes. These integrons are mostly known to carry
| |
| - | resistances to antibiotics. They are flanked with recombination sites which allow gene shuffling inside the integron thanks to a
| |
| - | specific enzyme: the integrase.
| |
| - | <br></br>
| |
| - | As a proof of concept, we are going to produce two antibiotics: Microcin C7 and Microcin B17. The first one inhibits a tRNA synthetase,
| |
| - | the second a gyrase. These two antibiotic operons encompass respectively 6 and 7 genes.
| |
| - | <br></br>
| |
| - | Two bacteria possessing the integron containing the antibiotics production gene cassettes, the integrase and a low resistance to the
| |
| - | opposite antibiotic will be put in competition. With the integrase, we could change the natural order of the genes in order to optimize
| |
| - | production. In parallel, this competition experiment will be modeled.</p>
| |
| - | </div>
| |
| | | | |
| | + | </font> |
| | | | |
| | | | |
| - | </body>
| |
| | </html> | | </html> |
"
