Team:Wageningen UR/Pnas ProjectOverview

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(Plug 'n Apply System)
(Plug 'n Apply System)
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== Plug 'n Apply System ==
== Plug 'n Apply System ==
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A big challenge of our project is the attachment of ligands and functional proteins on either the outside or inside of a virus-like particle (VLP). We decided to use a noncovalent anchor-like system, which consists of two different coiled-coil proteins. For various experiments the E-/K-coil combination IAAL E3 and IAAL K3 reported by Litowksi et al. in 2002 was used.
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A big challenge of our project is the attachment of ligands and functional proteins on either the outside or inside of a virus-like particle (VLP). The packaging of molecules and binding of ligands is achieved by an anchor-like system. Heterodimeric α-helical coiled coils are attached to the capsid proteins on the inside or outside of the three different viruses.
[[Team:Wageningen_UR/Coil_system|Read more]]
[[Team:Wageningen_UR/Coil_system|Read more]]

Revision as of 07:06, 19 September 2012

Plug 'n Apply System

A big challenge of our project is the attachment of ligands and functional proteins on either the outside or inside of a virus-like particle (VLP). The packaging of molecules and binding of ligands is achieved by an anchor-like system. Heterodimeric α-helical coiled coils are attached to the capsid proteins on the inside or outside of the three different viruses.

Read more