Team:Potsdam Bioware/slider

From 2012.igem.org

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                       Antibody module: In the first step an antibody gene is integrated into the genome of CHO cells.
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                       Antibody module: In the first, step an antibody gene is integrated into the genome of CHO cells.
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                       Selection Module: A virus infects cells with the “right” antibody. Those cells survive.
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                       Selection Module: A virus infects cells with high affine antibodies. Those cells survive.
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                       The „right“ cells are switched to antibody secreting cells with Cre-recombinase.
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                       The selected cells are switched to antibody secreting cells with Cre-recombinase.
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Revision as of 16:56, 26 September 2012

Antibody module: In the first, step an antibody gene is integrated into the genome of CHO cells.

Antibody module: The CHO-cell produces the antibody and presents it on the cell surface.

Mutation module: The enzyme AID mutates the antibody gene -> maturation

Selection Module: A virus infects cells with high affine antibodies. Those cells survive.

The selected cells are switched to antibody secreting cells with Cre-recombinase.

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