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Team:Trieste
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<a href="https://2012.igem.org/Team:Trieste/project/overview"target="_blank">Overview </a> - Have a look to our Jolly JoCare Project at a glance! | <a href="https://2012.igem.org/Team:Trieste/project/overview"target="_blank">Overview </a> - Have a look to our Jolly JoCare Project at a glance! | ||
Revision as of 08:49, 26 September 2012
Our Project
Quick Links
The Team
We present you the Jolly JoCare
Background
Recent studies have evidenced that having a beneficial and healthy
intestinal microflora is very important for human health.
Project
Our
aim is to modify a bacteria normally found in human gut and
create a safe, controllable and versatile molecular platform
which can be used to produce a wide range of molecules leading
to a beneficial probiotic. For this purpose we have chosen the
E. coli strain Nissle 1917 which has been used for many years as
a probiotic. We designed a robust gene guard system regulated
by a novel and easy to control inducible cumate switch that
activates the production of a human antimicrobial peptide LL-37
that can kill the bacteria and also avoid horizontal transfer.
Applications
The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.
