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Team:Dundee
From 2012.igem.org
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<li class='has-sub '><a href='#'><span>Team</span></a> | <li class='has-sub '><a href='#'><span>Team</span></a> | ||
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| - | <li><a href='https://2012.igem.org/Team:Dundee/Team'><span>Team | + | <li><a href='https://2012.igem.org/Team:Dundee/Team'><span>Team Members</span></a></li> |
<li><a href='https://igem.org/Team.cgi?year=2012&team_name=Dundee'><span>iGEM team Profile</span></a></li> | <li><a href='https://igem.org/Team.cgi?year=2012&team_name=Dundee'><span>iGEM team Profile</span></a></li> | ||
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<div style="margin-left: 40px; text-align: center;"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/b/b7/Homepic2.jpg"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/d/d0/Homepic1.jpg"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/e/ea/Homepic3.jpg"></div> | <div style="margin-left: 40px; text-align: center;"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/b/b7/Homepic2.jpg"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/d/d0/Homepic1.jpg"><img style="padding: 10px;" src="https://static.igem.org/mediawiki/2012/e/ea/Homepic3.jpg"></div> | ||
Revision as of 22:14, 12 September 2012
Clostridium difficile (C. diff) - associated disease of the gut is a major health problem, and current treatment methods are both ineffective and unpalatable. Previous research identified a C. diff-specific endolysin from the phage ΦCD27, which could be used to kill C. diff cells. Type VI secretions systems, found in a variety of organisms including Salmonella typhimurium, are characterised by a needle structure, the primary component of which is encoded by the gene Hcp. The tip of the needle is encoded by VgrG. The aim of this project was to create a new type of synthetic Escherichia coli expressing a simplified version of the Type VI Secretion System, with the C. diff-specific endolysin fused to VgrG, and which could be delivered to the gut to combat serious C. diff infections. Mathematical modelling was used to assist in the biological planning and a variety of relevant software applications were made.
