Team:WashU

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<!--Thanks to Imperial College London 2011 iGEM team for some of their code. Visit their web page here:https://2011.igem.org/Team:Imperial_College_London Thanks to UIUC Illinois 2012 for inspiration, as well.-->
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=='''Team''' ==
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The third ever Washington University iGEM team is composed of six undergraduate sophomores, juniors and seniors majoring in Biology, Biochemistry, and Biomedical Engineering. With the help of two mentors, Dr. Joe Jez and Dr. Gautam Dantas, and several graduate students (Brian Landry, Bert Berla, and Larry Page), the team decided to synthesize the components of saffron in the cyanobacterium Synechocystis.
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<div align = "center"><font size = "6">WashU iGEM 2012 takes gold at Americas East Jamboree!!!!!!</font></div>
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For all WashU students interested in joining the iGEM team of 2013, the application can be found <font size = "5"><a href="http://docs.google.com/spreadsheet/viewform?fromEmail=true&formkey=dE01RFZNeDN3Qjkxaktwc0VmUTFjOXc6MQ">here</a></font>. We will accept applications until February 15, 2013.
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<div align="center"><font size ="5">Project Abstract</font></div><br>
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For over a millennium, saffron has stood as the most expensive spice in the world, mostly due to the incredible amount of work required to extract the spice from the crocus flower. <br>
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Our iGEM team aims to produce saffron in the bacterium <i>E. coli</i>, in order to create an inexpensive alternative to the current method of manufacturing the spice. This project, named Saffron in a Kan, will seek to first express the genes necessary for the three main components of saffron - picrocin, crocin, and safranal - and then to optimize the output of these three components.
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A secondary goal for our team is to produce the above components in <i>Synechocystis</i>, a cyanobacterium, as well, to see if our biobrick can be used in more than one bacterium as well as to compare yield.
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== '''Project Abstract''' ==
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'''Saffron in a Kan'''
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[[Image:WashU_saffron.png|200px|right|Flower of ''Crocus sativus'', the natural source of saffron]]
 
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Saffron is renowned as one of the world's best spices, contributing both intense color and distinctive flavor to food.  Unfortunately, it also has a reputation for being the world's most expensive spice.  This is especially troubling given that recent research has suggested that extracts of saffron could serve a clinical role as both an anticarcinogenic and anti-depressive drug candidate.  [http://www.ncbi.nlm.nih.gov/pubmed/2025883] [http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2009.01133.x/abstract][http://onlinelibrary.wiley.com/doi/10.1002/ptr.3484/abstract;jsessionid=72474E49AC0D97B4252349D86064C49B.d02t04][http://www.actahort.org/books/650/650_54.htm].  In particular safranal and crocin, which also contribute to the flavor and color of saffron, have shown promise as clinical therapeutics.  Expression of these two products in an alternative species holds promise as a way to generate the supply needed for the clinical effects of saffron to be fully studied at a reasonable cost.  Similarly, they could also be used to make the flavor and color of saffron more widely available to those that cannot afford the natural product.
 
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''Synechocystis'', a model cyanobacteria, is a promising candidate for production of safranal and crocin. It is routinely used for cloning and already produces the precursor of both of these products, Zeaxanthin. Using the tools of synthetic biology, the WashU iGEM 2012 team hopes to successfully develop ''Synechocystis'' as a way to produce these valuable products.
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<a href="https://2012.igem.org/Team:WashU/Tour"><img src="https://static.igem.org/mediawiki/igem.org/c/c3/Project_Snapshot2.png" width="225px" style="padding:0px 0px 10px 0px;" /></a>
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<a href="https://2012.igem.org/Team:WashU/Achievements"><img src="https://static.igem.org/mediawiki/igem.org/1/17/Results.png" width="225px" style="padding:0px 0px 10px 0px;" /></a>
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<a href="https://2012.igem.org/Team:WashU/DesignSynecho"><img src="https://static.igem.org/mediawiki/igem.org/7/7d/Data.png" width="225px" style="padding:0px 0px 10px 0px;" /></a>
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<div id="sponsors" align="center"><font size="5">Sponsored by:</font>
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|<html><a href="http://www.sigmaaldrich.com/united-states.html/"><img src="https://lh4.googleusercontent.com/-HHdcaqLasPI/UCAnHNADv8I/AAAAAAAAAcI/nVJUzzal_aE/s800/sigma.png" width="544" height="181"></a></html>
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|<html><a href="http://www.dna20.com/"><img src="https://lh4.googleusercontent.com/-w8npjWbB5aI/UCAvucaWa0I/AAAAAAAAAc4/ryhV1fmSPfs/s800/DNA2.0.png" width="205" height=></a></html>
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'''YLC collaboration'''
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|<html><a href="http://www.monsanto.com/Pages/default.aspx"><img src="http://www.monsanto.com/SharedMonsantoLogos/media-kit/monsanto-thumb.png" width="205" ></a></html>
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|<html><a href="http://www.neb.com/nebecomm/default.asp"><img src="http://www.valaner.com/images/NEW%20ENGLAND%20BIOLABS.PNG" width="205" ></a></html>
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WashU iGEM has decided to conduct an outreach project in collaboration with The Youth Learning Center(YLC) here in St. Louis. The aim of this project is to introduce 6th to 8th graders to synthetic biology. In doing so, we hope to educate the students about the power of this new technology and the real challenges and concerns associated with it. How well we achieve this goal will be measured by giving a brief survey before and after our two days with the students. We will use the result of the project to make a series of short educational videos covering similar material that will be free to the public. The project will include having the students draw designs with fluorescent proteins.
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|<html><a href="http://www.invitrogen.com/site/us/en/home.html"><img src="https://static.igem.org/mediawiki/2012/3/32/Invitrogen_Logonoback.png" width="205"></a></html>
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|<html><a href="http://artsci.wustl.edu"><img src="https://lh6.googleusercontent.com/-WXf6gojyToE/UCA1O8UuILI/AAAAAAAAAdQ/VNO-EDolcMs/s800/ArtSci.png" height="131" width="200"></a></html>
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|<html><a href="http://engineering.wustl.edu"><img src="https://lh3.googleusercontent.com/-uwmaKRG-7R0/UCA1sURhMdI/AAAAAAAAAdg/y5Qkz9JhM4s/s800/engineering.png"></a></html>
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Latest revision as of 03:09, 30 January 2013




WashU iGEM 2012 takes gold at Americas East Jamboree!!!!!!


For all WashU students interested in joining the iGEM team of 2013, the application can be found here. We will accept applications until February 15, 2013.

Project Abstract

For over a millennium, saffron has stood as the most expensive spice in the world, mostly due to the incredible amount of work required to extract the spice from the crocus flower.
Our iGEM team aims to produce saffron in the bacterium E. coli, in order to create an inexpensive alternative to the current method of manufacturing the spice. This project, named Saffron in a Kan, will seek to first express the genes necessary for the three main components of saffron - picrocin, crocin, and safranal - and then to optimize the output of these three components.
A secondary goal for our team is to produce the above components in Synechocystis, a cyanobacterium, as well, to see if our biobrick can be used in more than one bacterium as well as to compare yield.

Locations of visitors to this page

Sponsored by:


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