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| - | </script><link rel="stylesheet" href="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/css&action=raw&ctype=text/css" type="text/css" /><link rel="stylesheet" href="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/css/lightbox&action=raw&ctype=text/css" type="text/css" /> | + | <td colspan="2" style="background-color:#FFF; padding:25px"><!-- InstanceBeginEditable name="EditRegion1" --> |
| - | <script type="text/javascript" src="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/js/jquery&action=raw&ctype=text/js"></script> | + | <p> </p> |
| - | <script type="text/javascript" src="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/js/easing&action=raw&ctype=text/js"></script> | + | <p class="aloveofthunder" style="line-height:normal; margin-bottom:35px">WELCOME!</p> |
| - | <script type="text/javascript" src="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/js/initjs&action=raw&ctype=text/js"></script>
| + | <p><strong><span style="color:#00C;font-size:16px"><em>“Let there be light”</em></span></strong>, it’s the start of our universe. We see the first light from sunrise and wake up. Have you imagined the bacteria can acquire the function of eyes, to “see” the color and respond to it? Our iGEM team applied the knowledge of synthetic biology to engineer the bacteria in order to make them sense different light color and decide to move toward or away from it. To play safe, we proposed a new biosafety approach to control the engineered bacteria from gene level. Below is the abstract of our project and you will find more information in our wiki website!</p> <p> </p> |
| - | <script type="text/javascript" src="https://2012.igem.org/wiki/index.php?title=Team:University_College_London/js/lightbox&action=raw&ctype=text/js"></script> | + | <p style="line-height:normal; font-size:36px; margin-bottom:30px">LIGHT OF NO RETURN </p> |
| - | <div id="ucligem"><div id="header" class="cover-choice">
| + | <p>Although the sensory technology has been deeply explored and implemented in various means, most of the developed sensors are chemically-dependent promoters which regulate downstream gene expression. We exploited the use of halobacterial sensors, the sensory rhodopsins which are sensitive to a wide spectrum of readily available light source and build a series of sensing systems to control cellular movement and gene regulation. This system can be executed as a fundamental part for further applications, such as cell targeting and refining. Furthermore, to counter the safety issues caused by the leakage of bioengineered cells, this sensing method altogether with the CRISPR/Cas sytem can target and achieve the cleavage of the transformed plasmid under the stimulation of natural light sources. </p> |
| - | <div id="top"><ul>
| + | <!-- InstanceEndEditable --></td> |
| - | <li><strong class="selflink">Home</strong></li>
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| - | <li><a href="/Team:University_College_London/Team" title="Team:University College London/Team">Team</a><ul>
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| - | <li><a href="/Team:University_College_London/Team" title="Team:University College London/Team">Team</a></li>
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| - | <li><a href="/Team:University_College_London/Press" title="Team:University College London/Press">Press</a></li>
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| - | <li><a href="/Team:University_College_London/ContactUs" title="Team:University College London/ContactUs">Contact Us</a></li><div class="bg"></div></ul></li>
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| - | <li><a href="/Team:University_College_London/Research" title="Team:University College London/Research">Research</a><ul>
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| - | <li><a href="/Team:University_College_London/Research" title="Team:University College London/Research">Overview</a></li>
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| - | <li><a href="/Team:University_College_London/Module_1" title="Team:University College London/Module 1">1:Detection</a></li>
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| - | <li><a href="/Team:University_College_London/Module_2" title="Team:University College London/Module 2">2:Aggregation</a></li>
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| - | <li><a href="/Team:University_College_London/Module_3" title="Team:University College London/Module 3">3:Degradation</a></li>
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| - | <li><a href="/Team:University_College_London/Module_4" title="Team:University College London/Module 4">4:Buoyancy</a></li>
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| - | <li><a href="/Team:University_College_London/Module_5" title="Team:University College London/Module 5">5:Salt Tolerance</a></li> | + | |
| - | <li><a href="/Team:University_College_London/Module_6" title="Team:University College London/Module 6">6:Containment</a></li>
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| - | <li><a href="/Team:University_College_London/BioBricks" title="Team:University College London/BioBricks">BioBricks</a></li>
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| - | <li><a href="/Team:University_College_London/LabSafety" title="Team:University College London/LabSafety">LabSafety</a></li><div class="bg"></div></ul>
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| - | <li><a href="/Team:University_College_London/HumanPractice" title="Team:University College London/HumanPractice">Human Practice</a><ul>
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| - | <li><a href="/Team:University_College_London/HumanPractice" title="Team:University College London/HumanPractice">Overview</a></li>
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| - | <li><a href="/Team:University_College_London/gemFM" title="Team:University College London/gemFM">gemFM</a></li>
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| - | <li><a href="/Team:University_College_London/HumanPractice/SpeedDebating" title="Team:University College London/HumanPractice/SpeedDebating">Speed Debating</a></li><div class="bg"></div></ul></li>
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| - | <li><a href="/Team:University_College_London/Achievements" title="Team:University College London/Achievements">Achievements</a></li>
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| - | <li><a href="/Team:University_College_London/Notebook" title="Team:University College London/Notebook" class="mw-redirect">Diary</a><ul>
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| - | <li><a href="/Team:University_College_London/Notebook" title="Team:University College London/Notebook" class="mw-redirect">Notebook</a></li>
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| - | <li><a href="/Team:University_College_London/LabBook" title="Team:University College London/LabBook" class="mw-redirect">Lab Book</a></li><div class="bg"></div></ul></li>
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| - | <li><a href="/Team:University_College_London/Sponsors" title="Team:University College London/Sponsors">Sponsors</a></li>
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| - | </ul>
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| - | <div id="igem"><a title="iGEM Home" href="http://www.igem.org" target="_blank"></a></div>
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| - | <div id="wikimenutoggleon"></div><div id="wikimenutoggleoff"></div>
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| - | </div></div>
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| - | <table id="toc" class="toc"><tr><td><div id="toctitle"><h2>Contents</h2></div>
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| - | <ul>
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| - | <li class="toclevel-1 tocsection-1"><a href="#Plastic_Republic"><span class="tocnumber">1</span> <span class="toctext">Plastic Republic</span></a>
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| - | <ul>
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| - | <li class="toclevel-2 tocsection-2"><a href="#Welcome_to_the_UCL_entry_for_iGEM_2012."><span class="tocnumber">1.1</span> <span class="toctext">Welcome to the UCL entry for iGEM 2012.</span></a></li>
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| - | <li class="toclevel-2 tocsection-3"><a href="#iGEM_Day_at_UCL:_August_20th"><span class="tocnumber">1.2</span> <span class="toctext">iGEM Day at UCL: August 20th</span></a></li>
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| - | <li class="toclevel-2 tocsection-4"><a href="#Plastic_Republic_-_Constructing_An_Island_From_Microplastic_Waste"><span class="tocnumber">1.3</span> <span class="toctext">Plastic Republic - Constructing An Island From Microplastic Waste</span></a></li>
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| - | <li class="toclevel-2 tocsection-5"><a href="#Maybe.2C_we.E2.80.99ll_see_you_on_Plastic_Republic_for_2030."><span class="tocnumber">1.4</span> <span class="toctext">Maybe, we’ll see you on Plastic Republic for 2030.</span></a></li>
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| - | </ul>
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| - | </li>
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| - | </ul>
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| - | </td></tr></table><script>if (window.showTocToggle) { var tocShowText = "show"; var tocHideText = "hide"; showTocToggle(); } </script>
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| - | <h1><span class="editsection">[<a href="/wiki/index.php?title=Team:University_College_London&action=edit&section=1" title="Edit section: Plastic Republic">edit</a>]</span> <span class="mw-headline" id="Plastic_Republic"> Plastic Republic </span></h1>
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| - | <h2><span class="editsection">[<a href="/wiki/index.php?title=Team:University_College_London&action=edit&section=2" title="Edit section: Welcome to the UCL entry for iGEM 2012.">edit</a>]</span> <span class="mw-headline" id="Welcome_to_the_UCL_entry_for_iGEM_2012.">Welcome to the UCL entry for iGEM 2012.</span></h2>
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| - | <div id="newtoigembutton"><a href="/Team:University_College_London/NewToIGEM" title="Team:University College London/NewToIGEM">New to iGEM? Start our wiki tour here!</a></div>
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| - | <p><br />
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| - | UCL iGEM proposes a synthetic biology approach for the bioremediation of micro-plastic pollutants within the marine environment, with emphasis on regions of excessive debris accumulation, such as the North Pacific ‘garbage patch’.
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| - | </p><p>We intend to engineer enhanced adhesive properties in <i>Escherichia coli</i> and marine bacteria <i>Roseobacter denitrifican</i> and <i>Oceanibulbus indolifex</i>, of the <i>Roseobacter</i> clade. To alter the composition and dynamics of resultant biofilms for the adhesion of micro-plastic pollutants, with an extended vision of creating mass aggregates, or ‘Plastic Islands’.
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| - | </p><p>We will attempt to demonstrate micro-plastic particle aggregation and several additional genetic components, including plastic degradation, salinity/osmotic tolerance in <i>E. coli</i>, bacterial buoyancy and novel active biological containment strategies, for an integrative approach to marine bioremediation.
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| - | </p><p><i><b>Update:</b></i> Read about Plastic Republic on <a href="http://www.wired.co.uk/news/archive/2012-07/18/nanobots-recycling-plastic" title="Article" target="_blank">Wired</a>, <a href="http://dvice.com/archives/2012/07/students-synthe.php" title="Article" target="_blank">DVICE</a> and <a href="http://blogs.smithsonianmag.com/smartnews/2012/07/synthetic-bacteria-could-turn-ocean-garbage-into-one-big-island/" title="Article" target="_blank">Smithsonian</a>!
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| - | </p>
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| - | <h2><span class="editsection">[<a href="/wiki/index.php?title=Team:University_College_London&action=edit&section=3" title="Edit section: iGEM Day at UCL: August 20th">edit</a>]</span> <span class="mw-headline" id="iGEM_Day_at_UCL:_August_20th"> iGEM Day at UCL: August 20th </span></h2>
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| - | <p><div align="center"><a target="_blank" title="Meet UCL iGEM" href="http://www.engineering.ucl.ac.uk/blog/events/meet-ucl-igem/"><img src="https://static.igem.org/mediawiki/2012/1/10/Ucl2012-igemday-banner.jpg" /></a></div>
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| - | </p>
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| - | <h2><span class="editsection">[<a href="/wiki/index.php?title=Team:University_College_London&action=edit&section=4" title="Edit section: Plastic Republic - Constructing An Island From Microplastic Waste">edit</a>]</span> <span class="mw-headline" id="Plastic_Republic_-_Constructing_An_Island_From_Microplastic_Waste">Plastic Republic - Constructing An Island From Microplastic Waste</span></h2>
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| - | <p><i>Turning a Global Problem into a Valuable Resource: We Aim to Engineer Bacteria to Aggregate Tonnes of Microplastic Pollution into ‘Plastic Islands’, in order to Reclaim Plastic for Re-Use.</i>
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| - | <div style="float:right"><a href="http://www.plasticrepublic.org" title="Plastic Republic - Land for Sale" target="_blank"><img src="https://static.igem.org/mediawiki/2012/c/c5/Ucl2012-landforsalebanner.jpg" alt="Land For Sale" /></a></div>
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| - | </p><p><br />
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| - | <iframe width="560" style="z-index:1" height="315" src="http://www.youtube.com/embed/rEDLg03teOk" frameborder="0" allowfullscreen></iframe>
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| - | </p><p><a href="http://www.sponsume.com/project/plastic-republic" class="external text" rel="nofollow">Take a look at our fundraising video and become a supporter of our project!</a>
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| - | </p><p>After months of planning, we are now rallying to construct a ‘plastic island’ using the principles of synthetic biology. In so doing we hope to provide a solution to one of the world’s major environmental problems – the North Pacific Garbage Patch. | + | </tr> |
| - | </p><p>The North Pacific Garbage Patch is the largest of many garbage patches identified around the world. The waste from these patches enters the digestive systems of resident organisms, which are affected either by the physical size of the plastic, or its toxicity from adsorbing organic pollutants. | + | </table> |
| - | </p><p>We saw the merits of using synthetic biology to overcome this problem, especially as conventional methods cannot target the majority of the waste - microplastics. By ‘synthesising’ a new strain of bacteria, capable of detecting, aggregating, and buoying these elusive microplastics, we aim to construct ‘Plastic Islands’ for | + | </body> |
| - | </p> | + | </html> |
| - | <ol><li>Removal and Re-use
| + | {{:Team:Hong_Kong-CUHK/footer}} |
| - | </li><li>Construction of a ‘Plastic Republic’
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| - | </li></ol>
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| - | <p>Please visit our <a href="/Team:University_College_London/Research" title="Team:University College London/Research">Research page</a> for more background and details on the above, and our <a href="/Team:University_College_London/HumanPractice" title="Team:University College London/HumanPractice">Human Practice page</a> page for how we aim to encourage outside involvement in this project.
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| - | </p>
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| - | <h2><span class="editsection">[<a href="/wiki/index.php?title=Team:University_College_London&action=edit&section=5" title="Edit section: Maybe, we’ll see you on Plastic Republic for 2030.">edit</a>]</span> <span class="mw-headline" id="Maybe.2C_we.E2.80.99ll_see_you_on_Plastic_Republic_for_2030.">Maybe, we’ll see you on Plastic Republic for 2030. </span></h2>
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