Team:Trieste

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<h1 id="h1_lf" class="main_tit"><div>Our Project</div></h1>
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<h1 id="h1_mn" class="main_tit"><div>Quick Links</div></h1>
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<h1 id="h1_rt" class="main_tit"><div>The Team</div></h1>
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<h2>We present you the Jolly JoCare</h2>
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<iframe width="330" height="280" src="http://www.youtube.com/embed/vB5xmbLnj7I" frameborder="0" allowfullscreen></iframe>
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<p>
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<a href="https://2012.igem.org/Team:Trieste/project/overview" target="_blank">Project Overview</a>
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- Have a look to our Jolly JoCare Project at a glance!
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<p>
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<strong> Abstract </strong> <br/>
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Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules  leading to a beneficial probiotic. For this purpose we have chosen the <i>E. coli</i> strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer. 
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The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.
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<div class="title">Achievements</div>
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<div class="date">  </div>
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<div class="intro">
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<a href="https://2012.igem.org/Team:Trieste/extra/ach"target="_blank">Quick link</a>
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to our judging form and Achievements summary<br/>
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<div class="read_more">
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<a href="https://2012.igem.org/Team:Trieste/extra/ach" target="_blank">a</a>
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<div class="title">Main Results</div>
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<div class="date">  </div>
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<div class="intro">
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<a href="https://2012.igem.org/Team:Trieste/project/mainres" target="_blank">Click here</a> to reach our summary page.
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<a href="https://2012.igem.org/Team:Trieste/project/mainres"target="_blank">a</a>
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<div class="article">
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<div class="title">Data</div>
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<div class="date">  </div>
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<div class="intro"><a href="https://2012.igem.org/Team:Trieste/data"target="_blank">Here</a> are our favourite parts!</div> </br>
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<div class="read_more"><a href="https://2012.igem.org/Team:Trieste/data"target="_blank">a</a></div>
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</div>
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<img src="https://static.igem.org/mediawiki/2012/6/64/Foto_home_cumato_tag.jpg"alt="#" width="300px"/>
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<img src="https://static.igem.org/mediawiki/2012/b/b0/Team_trieste.jpg" alt="Team iGEM 2012" id="igem_team" />
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<h2>Contact us</h2>
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<p>For other information, write to:</p>
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<a href="mailto:igem2012@gmail.com" class="btn">igem2012@gmail.com</a>
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<div class="social">
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Follow us also:
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<a href="https://www.facebook.com/IGEMUNITS?ref=ts" target="_blank"><img src="https://static.igem.org/mediawiki/2012/f/f4/Ico_fb.png" alt="Facebook" class="fb" /></a>
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<a href="https://twitter.com/iGEMTrieste" target="_blank"><img src="https://static.igem.org/mediawiki/2012/2/21/Ico_twitter.png" alt="twitter" class="tw" /></a>
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</div>
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</div>
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<br/> <br/><br/>
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<img src="https://static.igem.org/mediawiki/2012/7/70/Trieste_foto_home_2.jpg" alt="sec photo team trieste" width="230px" height="140" />
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace. 
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
 
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''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
 
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|align="center"|[[Team:Trieste | Team Trieste]]
 
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!align="center"|[[Team:Trieste|Home]]
 
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!align="center"|[[Team:Trieste/Team|Team]]
 
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!align="center"|[https://igem.org/Team.cgi?year=2012&team_name=Trieste Official Team Profile]
 
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!align="center"|[[Team:Trieste/Project|Project]]
 
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!align="center"|[[Team:Trieste/Parts|Parts Submitted to the Registry]]
 
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!align="center"|[[Team:Trieste/Modeling|Modeling]]
 
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!align="center"|[[Team:Trieste/Notebook|Notebook]]
 
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!align="center"|[[Team:Trieste/Safety|Safety]]
 
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!align="center"|[[Team:Trieste/Attributions|Attributions]]
 
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Latest revision as of 02:10, 27 September 2012

Our Project

Quick Links

The Team

We present you the Jolly JoCare

Project Overview - Have a look to our Jolly JoCare Project at a glance!

Abstract
Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules leading to a beneficial probiotic. For this purpose we have chosen the E. coli strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer. The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.

Achievements
Quick link to our judging form and Achievements summary
a
Main Results
Click here to reach our summary page.
a
Data
Here are our favourite parts!

a

#
Team iGEM 2012

Contact us

For other information, write to:

igem2012@gmail.com



sec photo team trieste
Università degli studi di Trieste ICGEB Illy Fondazione Cassa di Risparmio
iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012 iGEM 2012
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