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Team:Trieste
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<h2>We present you the Jolly JoCare</h2> | <h2>We present you the Jolly JoCare</h2> | ||
<iframe width="330" height="280" src="http://www.youtube.com/embed/vB5xmbLnj7I" frameborder="0" allowfullscreen></iframe> | <iframe width="330" height="280" src="http://www.youtube.com/embed/vB5xmbLnj7I" frameborder="0" allowfullscreen></iframe> | ||
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<p> | <p> | ||
| - | <a href="https://2012.igem.org/Team:Trieste/project/overview"target="_blank">Project Overview</a> | + | <a href="https://2012.igem.org/Team:Trieste/project/overview" target="_blank">Project Overview</a> |
- Have a look to our Jolly JoCare Project at a glance! | - Have a look to our Jolly JoCare Project at a glance! | ||
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Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules leading to a beneficial probiotic. For this purpose we have chosen the <i>E. coli</i> strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer. | Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules leading to a beneficial probiotic. For this purpose we have chosen the <i>E. coli</i> strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer. | ||
The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus. | The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus. | ||
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<div class="read_more"><a href="https://2012.igem.org/Team:Trieste/data"target="_blank">a</a></div> | <div class="read_more"><a href="https://2012.igem.org/Team:Trieste/data"target="_blank">a</a></div> | ||
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</ul> | </ul> | ||
<img src="https://static.igem.org/mediawiki/2012/b/b0/Team_trieste.jpg" alt="Team iGEM 2012" id="igem_team" /> | <img src="https://static.igem.org/mediawiki/2012/b/b0/Team_trieste.jpg" alt="Team iGEM 2012" id="igem_team" /> | ||
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Follow us also: | Follow us also: | ||
<a href="https://www.facebook.com/IGEMUNITS?ref=ts" target="_blank"><img src="https://static.igem.org/mediawiki/2012/f/f4/Ico_fb.png" alt="Facebook" class="fb" /></a> | <a href="https://www.facebook.com/IGEMUNITS?ref=ts" target="_blank"><img src="https://static.igem.org/mediawiki/2012/f/f4/Ico_fb.png" alt="Facebook" class="fb" /></a> | ||
| - | <a href="https://twitter.com/ | + | <a href="https://twitter.com/iGEMTrieste" target="_blank"><img src="https://static.igem.org/mediawiki/2012/2/21/Ico_twitter.png" alt="twitter" class="tw" /></a> |
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| - | <img src="https://static.igem.org/mediawiki/2012/ | + | <img src="https://static.igem.org/mediawiki/2012/7/70/Trieste_foto_home_2.jpg" alt="sec photo team trieste" width="230px" height="140" /> |
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Latest revision as of 02:10, 27 September 2012
The Jolly JoCare
a safe probiotic platform for protein expression
Our Project
Quick Links
The Team
We present you the Jolly JoCare
Project Overview - Have a look to our Jolly JoCare Project at a glance!
Abstract
Recent studies have evidenced that having a beneficial and healthy intestinal microflora is very important for human health. Our aim is to modify a bacteria normally found in human gut and create a safe, controllable and versatile molecular platform which can be used to produce a wide range of molecules leading to a beneficial probiotic. For this purpose we have chosen the E. coli strain Nissle 1917 which has been used for many years as a probiotic. We designed a robust gene guard system regulated by a novel and easy to control inducible cumate switch that activates the production of a human antimicrobial peptide LL-37 that can kill the bacteria and also avoid horizontal transfer.
The safe probiotic constructed here can be used to produce nutritious, preventive or therapeutic molecules. For example, we have used it to produce an antibody against the emerging virus, Norovirus.
