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Team:Wageningen UR/OutsideModification ProjectOverview
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<html><!-- By adding a k-coil to the outside of a VLP, the P’nAS system can be used to attach any ligand or antigen to the particle.--></html> | <html><!-- By adding a k-coil to the outside of a VLP, the P’nAS system can be used to attach any ligand or antigen to the particle.--></html> | ||
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| - | The monomers of virus-like particles (VLPs) have been subject to many modifications of which some are aimed at changing the appearance of the particle. By changing the outside, the VLP acquires new properties which have been used mainly in vaccine development | + | The monomers of virus-like particles (VLPs) have been subject to many modifications of which some are aimed at changing the appearance of the particle. By changing the outside, the VLP acquires new properties which have been used mainly in vaccine development. The modification we pursue is adding a coil to the protein subunits, at any location that is exposed on the outside of the VLP. This can be a fusion to a C or N-terminal, but a modification in a loop is possible as well. The goal of the coil is to serve as a docking site for ligands which are modified to contain a coil subunit. A coil on the outside plays a rather important role expanding the applications of VLPs. It forms the link between the VLP and a functional group, such as a ligand or antigen. |
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[[Team:Wageningen_UR/OutsideModification|Read more]] | [[Team:Wageningen_UR/OutsideModification|Read more]] | ||
Latest revision as of 10:01, 26 September 2012
Modifying the outside of a VLP
The monomers of virus-like particles (VLPs) have been subject to many modifications of which some are aimed at changing the appearance of the particle. By changing the outside, the VLP acquires new properties which have been used mainly in vaccine development. The modification we pursue is adding a coil to the protein subunits, at any location that is exposed on the outside of the VLP. This can be a fusion to a C or N-terminal, but a modification in a loop is possible as well. The goal of the coil is to serve as a docking site for ligands which are modified to contain a coil subunit. A coil on the outside plays a rather important role expanding the applications of VLPs. It forms the link between the VLP and a functional group, such as a ligand or antigen.
