Team:Peking/HumanPractice/Outreach/Collaboration

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  <h3 id="title1">Summary</h3>
  <h3 id="title1">Summary</h3>
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In order to get in touch with the high schools in Beijing and to ensure our propagation of Synthetic Biology to be a long-term project, we went to Beijing Teenageer Science & Technology Club for help and gave a presentation to the chief secretary and other teachers. Our efforts impressed them and finally we agreed to work together. The club also paved the way for our lectures.
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This summer, our team benefitted a lot from the collaboration with Prof. YANG Yi and other iGEM teams. By paying reciprocal visits with Prof. Yang, we establish collaboration with his lab. By helping some other teams with their contests, we built lifelong friendship with team members across the world.
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  <h3 id="title2">Reciprocal visit with Prof. Yang Yi <br /> & Request for VVD</h3>
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  <h3 id="title2">Collaboration with Prof. YANG Yi's Lab</h3>
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Greatly inspired by the elaborate design of an ultrasensitive, light-controlled and genetically encoded transactivator Gal4-VVD [1], Peking 2012 iGEM team, who intend to introduce a similar light-switchable transgene system into E. coli, invited Prof. Yi Yang from East China University of Science and Technology to come to Peking and communicate with the team members. Later, Peking 2012 team members also made another visit to Prof. Yang.
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As a burgeoning interface of biology, chemistry, physics and many other disciplines of research, the study of synthetic biology highly values and is critically depended on the collaboration of different specialities and different groups. Aiming at the optimization and further application of an ultra-sensitive light sensor, our team decided to collaborate with Prof. YANG Yi’s group from ECUST (East China University of Science and Technology) and research under the instruction of Prof. YANG.  
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The publication [1] of an ultra photosensitive, genetically encoded positive regulator, Gal4-VVD, which is rationally designed to enjoy a high spatiotemporal specificity and efficiency, greatly enlightened the Peking 2012 iGEM team on its primitive aim for programming cells to function and communicate through light.
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Upon his visit to Peking University this May, Prof. YANG presented his design and preliminary results on the Light-OFF system and we shared our opinions on its further applications. And in this very meeting, both sides decided to combine each component of their works and present this project in the iGEM competition.  
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By sharing a mutual concern of introducing a similar system into E. coli for synthetic biological application, Prof. Yi Yang from East China University of Science and Technology and our team paid reciprocal visits to each other. During Prof. Yang’s visit to Peking University on 21st April, we established a consensus for the basic construction of further cooperation and shared a common view on the basic design of a LexA-VVD genetic regulator.
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<img src="https://static.igem.org/mediawiki/igem.org/c/c1/Peking2012_HS_yangyi.JPG" alt="Prof.Yang Yi">
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Two months later, deputy team leader Wenyuan Nathan Zhou and team member Jiawei Yan visited Yang lab in Shanghai to exchange ideas on experimental data & details and to obtain Prof. Yang’s prototype of genetic construction of the fusion protein.
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<p class="description" style="text-align:center">Professor YANG Yi</p>
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This very cooperation is not only beneficial to both sides, but also provides an opportunity for future collaborations.
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  <p>Based on the original work of YANG’s group, team members in Peking University endeavored in the possible extension of this light sensitive and functional Light-OFF biobrick.  
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  <img src="/wiki/images/2/2e/Peking2012_Forming_Alliance_with_BTSTC.JPG" alt="Figure 4. Forming Alliance with BTSTC" title="Figure 4. Forming Alliance with BTSTC" style="width:500px;" />
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Figure 4. On June 20th, we went to the office of the Beijing Teenager Science & Technology Club, and gave a presentation to teachers in all high schools in Beijing.
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On June 20th, some of us went to the office of the Beijing Teenager Science & Technology Club, and gave a presentation to Ms Zhou Lin, the Chief Secretary of the club and all other teachers who are responsible for the science affairs of their own schools. The presentation was very successful! The teachers not only realized the basic ideas of Synthetic Biology and the concept of iGEM, but also they figured out the long-term potential of this subject, and the meaning of iGEM to students --- motivating them to study Synthetic Biology in a collaboratary and interdisciplinary atmosphere and to become excellent synthetic biologists in the future.
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Ms Zhou Lin rejoicingly told us that she was impressed by our efforts on spreading nowadays science frontiers to the young generation of students and decided to ally with Peking iGEM from now on and help us accomplish the goal of "Sowing Tomorrow Synthetic Biologists".
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  <h3 id="title3">Propagation for Lecture</h3>
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  <h3 id="title3">Collaboration with Other iGEM Teams</h3>
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In order to ensure our lecture to hold without impediment, Ms Zhou agreed to offer a hall for us. Furthermore, the teachers from all high schools in Beijing said that they were very glad to help inform their students to attend our lecture, and they even took all the propagation materials we prepared for the lecture, including the fliers and guiding brochure we made for students with interests.
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  <img src="/wiki/images/b/b2/Peking2012_HP_SJTU_logo.jpg" alt="SJTU_iGEM" style="width:200px;">
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   <p style="font-weight:bold;width:150px;text-align:center;margin:0 auto;">SJTU_iGEM</p>
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  <img src="/wiki/images/f/f0/Peking2012_Propagation_Poster.jpg" alt="Figure 6. Poster of our lecture" title="Figure 6. Poster of our lecture" style="width:280px;" />
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Figure 6. Poster of our lecture "Life as machines --- Rational Design for Artificial Biological Systems".
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Another important part of iGEM is helping other teams through communication and collaboration. <a href="/Team:SJTU-BioX-Shanghai">Team SJTU-BioX-Shanghai</a> found that we utilized ribozymes last year to control the expression of VioABDE gene, and thereby requested biobricks of <a href="http://partsregistry.org/wiki/index.php?title=Part:BBa_K598019"> BBa_K598019</a> and <a href="http://partsregistry.org/wiki/index.php?title=Part:BBa_K598020">BBa_K598020</a> to incorporate in their "Membrane Magic" project. We shared the DNA materials with them.
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   <img src="/wiki/images/b/b9/Peking2012_Propagation_Brochure1.JPG" alt="Figure 5. Brochure for iGEM HS-Division" title="Figure 5. Brochure for iGEM HS-Division" style="width:300px;" />
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   <img src="http://partsregistry.org/wiki/images/3/36/PekingR_ZZR2.JPG" alt="BBa_K598019" style="width:500px;">
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  <p class="description" style="width:150px;text-align:center;">BBa_K598019</p>
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   <img src="https://static.igem.org/mediawiki/igem.org/5/56/Peking2012_HS_Tinjin.png" alt="TJU_iGEM" style="width:200px;">
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  <p style="font-weight:bold;width:150px;text-align:center;margin:0 auto;">TJU_iGEM Team</p>
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  <p>We also collaborated with <a href="/Team:Tianjin">Team Tianjin</a> by sharing ideas, protocols and information. Later, we helped them to characterize their biobricks <a href="http://partsregistry.org/wiki/index.php?title=Part:BBa_K821001"> BBa_K821001</a> and <a href="http://partsregistry.org/wiki/index.php?title=Part:BBa_K821002"> BBa_K821002</a> using fluorescence stereomicroscope.
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  <div class="floatC"><p style="width:600px;height:50px;"></p></div>
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   <img src="/wiki/images/2/2c/Peking2012_Propagation_Brochure2.JPG" alt="Figure 5. Brochure for iGEM HS-Division" title="Figure 5. Brochure for iGEM HS-Division" style="width:300px;" />
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  <p class="description" style="width:300px;">
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  <img src="https://static.igem.org/mediawiki/igem.org/6/64/Peking2012_HS_OUC.jpg" alt="OUC_iGEM" style="width:200px;">
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Figure 5. In order to guide high school students to take part in the iGEM HS-Division competition, we organized all the related material and made a brochure for the competition. We gave the brochures to the students for propagation before and after our lectures.
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  <p style="font-weight:bold;width:150px;text-align:center;margin:0 auto;">OUC_iGEM Team</p>
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Also we established a positive, cooperative, and steady relation with <a href="/Team:OUC-China">OUC-China</a>. Our team and OUC iGEM helped each other a lot this summer. We helped them to build stochastic model and gave some important advice about their program, which provides guidance for the experimental implementation.  Reciprocally, they shared DNA material of agarase, an enzyme that degrades agar, with us, which is very useful for our 3D bio-printing.
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  <img src="/wiki/images/4/4b/Peking2012_HP_OUC_result.jpg" alt="" style="width:500px;">
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   <p class="description" style="width:150px;text-align:center;">OUC_iGEM Result</p>
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  <img src="/wiki/images/d/dc/Peking2012_HS_SYSU.jpg" alt="SYSU_iGEM" style="width:200px;">
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   <p style="font-weight:bold;width:150px;text-align:center;margin:0 auto;">SYSU_iGEM Team</p>
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Besides, we also shared DNA materials of <a href="http://partsregistry.org/wiki/index.php?title=Part:BBa_K598002"> BBa_K598002</a> with <a href="/Team:SYSU-China">Team SYSU-China</a>. They exploited this digital-like and plug-in toggle switch to implement sequential logic processing in their gene circuit.
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  <img src="/wiki/images/8/8c/Peking_Collaboration_SYSU_Fluorescence_images_of_bistable_switch.png" alt="Bistable" style="width:400px;">
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   <p class="description" style="text-align:center;">Fluorescence images of bistable switch.</p>
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  <p style="text-align:center;width:270px;"><a href="/wiki/images/c/ce/Peking2012_Brochure.pdf">Brochure for iGEM HS-Division.</a></p>
 
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  <p style="text-align:center;width:270px;"><a href="/wiki/images/2/25/Peking2012_Flier.pdf">Flier for the Lecture.</a></p>
 
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Coming back from the club, we made a poster for our lecture. Then we sent each high school with several pieces of the poster and even put the electronic version on our website <a href="http://page.renren.com/601444914">Peking iGEM</a> on Renren to publicize our coming lectures.
 
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Latest revision as of 06:10, 24 October 2012

Summary

This summer, our team benefitted a lot from the collaboration with Prof. YANG Yi and other iGEM teams. By paying reciprocal visits with Prof. Yang, we establish collaboration with his lab. By helping some other teams with their contests, we built lifelong friendship with team members across the world.

Collaboration with Prof. YANG Yi's Lab

As a burgeoning interface of biology, chemistry, physics and many other disciplines of research, the study of synthetic biology highly values and is critically depended on the collaboration of different specialities and different groups. Aiming at the optimization and further application of an ultra-sensitive light sensor, our team decided to collaborate with Prof. YANG Yi’s group from ECUST (East China University of Science and Technology) and research under the instruction of Prof. YANG.

Upon his visit to Peking University this May, Prof. YANG presented his design and preliminary results on the Light-OFF system and we shared our opinions on its further applications. And in this very meeting, both sides decided to combine each component of their works and present this project in the iGEM competition.

Prof.Yang Yi

Professor YANG Yi

Based on the original work of YANG’s group, team members in Peking University endeavored in the possible extension of this light sensitive and functional Light-OFF biobrick.

Collaboration with Other iGEM Teams

SJTU_iGEM

SJTU_iGEM

Another important part of iGEM is helping other teams through communication and collaboration. Team SJTU-BioX-Shanghai found that we utilized ribozymes last year to control the expression of VioABDE gene, and thereby requested biobricks of BBa_K598019 and BBa_K598020 to incorporate in their "Membrane Magic" project. We shared the DNA materials with them.

BBa_K598019

BBa_K598019

TJU_iGEM

TJU_iGEM Team

We also collaborated with Team Tianjin by sharing ideas, protocols and information. Later, we helped them to characterize their biobricks BBa_K821001 and BBa_K821002 using fluorescence stereomicroscope.

OUC_iGEM

OUC_iGEM Team

Also we established a positive, cooperative, and steady relation with OUC-China. Our team and OUC iGEM helped each other a lot this summer. We helped them to build stochastic model and gave some important advice about their program, which provides guidance for the experimental implementation. Reciprocally, they shared DNA material of agarase, an enzyme that degrades agar, with us, which is very useful for our 3D bio-printing.

OUC_iGEM Result

SYSU_iGEM

SYSU_iGEM Team

Besides, we also shared DNA materials of BBa_K598002 with Team SYSU-China. They exploited this digital-like and plug-in toggle switch to implement sequential logic processing in their gene circuit.

Bistable

Fluorescence images of bistable switch.

  • Totop Totop

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