Team:ULB-Brussels/Modeling

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{| style="color:#1b2c8a;background-color:#fff;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="100%" align="center"
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!align="center"|[[Team:ULB-Brussels|Home]]
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!align="center"|[[Team:ULB-Brussels/Team|Team]]
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!align="center"|[[Team:ULB-Brussels/Project|Project]]
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!align="center"|[[Team:ULB-Brussels/Parts|Parts]]
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!align="center"|[[Team:ULB-Brussels/Modeling|Modeling]]
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!align="center"|[[Team:ULB-Brussels/Conclusion|Conclusion & Perspectives]]
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!align="center"|[[Team:ULB-Brussels/Safety|Safety]]
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!align="center"|[[Team:ULB-Brussels/Previous|Older wiki's]]
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<li><a href="https://2012.igem.org/Team:ULB-Brussels"></a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Team">&nbsp; Our Team &nbsp;</a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Project">&nbsp; The Project &nbsp;</a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Parts">&nbsp; Parts submitted &nbsp;</a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Notebook">&nbsp; Notebook &nbsp;</a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Safety">&nbsp; Safety &nbsp;</a></li>
 
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<li><a href="https://2012.igem.org/Team:ULB-Brussels/Attributions">&nbsp; Attributions &nbsp;</a></li>
 
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                <li><a href="https://2012.igem.org/Team:ULB-Brussels/Previous">&nbsp; Older wikis &nbsp;</a></li>
 
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<center><font color="#000000"; size="100"> Team ULB-Brussels, modeling of our </font></center>
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<br></br><p><center><font color="#000000"; size="100"> project! </font></center></p>
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<font color=#1D702D;background-color:#FC7F3C;><font Size="100"><p>  Team ULB-Brussels, welcome to our wiki! </p></font>
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<h2>Abstract of our project</h2>
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<p><font size="+3"> An online version of the report can be found <a href="http://www.mediafire.com/view/?ubp5sobban0b9l6">here</a>.</font>
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<p>In synthetic biology, one of the main issues scientists and engineers must tackle is biochemical pathways optimization.
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In fact, it is often difficult to predict in which positions the genes of the pathway must be assembled in order to efficiently
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produce the desired molecule.
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In this project, we are going to develop an exceptional natural tool that could be used to optimize bio-production pathways:
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<embed src="http://data.axmag.com/data/201209/U59129_F130176/main.swf?page=81" quality="high" width="100%" height="650px"; scale="noscale" align="TL" salign="TL" allowFullScreen="true" type="application/x-shockwave-flash"></embed>
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the integron. Integrons are genetic platforms which contain (re)movable gene cassettes. These integrons are mostly known to carry
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resistances to antibiotics. They are flanked with recombination sites which allow gene shuffling inside the integron thanks to a
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specific enzyme: the integrase.
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As a proof of concept, we are going to produce two antibiotics: Microcin C7 and Microcin B17. The first one inhibits a tRNA synthetase,
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the second a gyrase. These two antibiotic operons encompass respectively 6 and 7 genes.
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Here are the several graphs that did not appear on the reading version above.
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Two bacteria possessing the integron containing the antibiotics production gene cassettes, the integrase and a low resistance to the
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opposite antibiotic will be put in competition. With the integrase, we could change the natural order of the genes in order to optimize
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production. In parallel, this competition experiment will be modeled.</p>
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<font size="+0"> Figures 1-8</font>
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<font size="+0"> Figure 9</font>
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<center><td><a href="http://www.ulb.ac.be/facs/sciences/index.html"><img id="logo" src="https://static.igem.org/mediawiki/2012/8/87/Logo-sciences.png" height="120px" width="300px"></a>
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<td><a href="http://www.ulb.ac.be/"><img id="logo" src="https://static.igem.org/mediawiki/2012/0/0e/Logo-ULB.jpg" height="120px" width="120px"></a>
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<td><a href="http://www.ulb.ac.be/inforsciences3/accueil/">
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Latest revision as of 23:30, 26 September 2012

Home Team Project Parts Modeling Conclusion & Perspectives Safety Older wiki's


 

Team ULB-Brussels, modeling of our


project!



An online version of the report can be found here.



Here are the several graphs that did not appear on the reading version above.



Figures 1-8



Figure 9