Team:Virginia

From 2012.igem.org

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<body>
<body>
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<navig></navig>
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<navig><ul id="tabnav">
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<li class="tab2"><a href="/Team:Virginia/Project">Project</a></li>
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<li class="tab4"><a href="/Team:Virginia/Parts">Parts</a></li>
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        <li class="tab8"><a href="/Team:Virginia/Team">Team</a></li>
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<li class="tab9"><a href="/Team:Virginia/Practices">Practices</a></li>
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<li class="tab5"><a href="/Team:Virginia">
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&nbsp;&nbsp;<img src="https://static.igem.org/mediawiki/2012/b/b8/Igemlogo.fw.png" border="0"/>&nbsp;&nbsp;</a></li>
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<li class="tab3"><a href="/Team:Virginia/Modeling">Modeling</a></li>
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<li class="tab6"><a href="http://openwetware.org/wiki/IGEM:Virginia_2012">Notebook</a></li>
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<li class="tab7"><a href="/Team:Virginia/Safety">Safety</a></li>
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<li class="tab7"><a href="/Team:Virginia/Attributions">Attributions</a></li>
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</p><p><br />
</p><p><br />
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<table style="" cellpadding="3" cellspacing="1" width="100%" align="center">
 
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<tr>
 
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<th align="center"><strong class="selflink">Home</strong>
 
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</th><th align="center"><a href="/Team:Virginia/Team" title="Team:Virginia/Team">Team</a>
 
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</th><th align="center"><a href="https://igem.org/Team.cgi?year=2012&amp;team_name=Virginia" class="external text" rel="nofollow">Official Team Profile</a>
 
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</th><th align="center"><a href="/Team:Virginia/Project" title="Team:Virginia/Project">Project</a>
 
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</th><th align="center"><a href="/Team:Virginia/Parts" title="Team:Virginia/Parts">Parts Submitted to the Registry</a>
 
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</th><th align="center"><a href="/Team:Virginia/Modeling" title="Team:Virginia/Modeling">Modeling</a>
 
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</th><th align="center"><a href="/Team:Virginia/Notebook" title="Team:Virginia/Notebook">Notebook</a>
 
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</th><th align="center"><a href="/Team:Virginia/Safety" title="Team:Virginia/Safety">Safety</a>
 
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</th><th align="center"><a href="/Team:Virginia/Attributions" title="Team:Virginia/Attributions">Attributions</a>
 
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<p><br />
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<a href="/Team:Virginia/Project">
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<img src="https://static.igem.org/mediawiki/2012/2/22/Hgc.fw.png" alt="some_text"/>
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<img src="https://static.igem.org/mediawiki/igem.org/2/2e/LogoHCG3.png" alt="Logo VGEM" align="absmiddle" class="centering"/></a>
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<br /><br />
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<h1><center>Genetically engineered bacteriophage for diagnosis of whooping cough</h1></center><br/>
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We are engineering bacteriophage to accelerate diagnosis of whooping cough. Whooping cough outbreaks arise periodically every three to five years (in the 2010 epidemic in California, there were 9,143 reported cases of pertussis, including ten infant deaths). It is difficult to diagnose whooping cough because other respiratory infections cause similar symptoms, and common diagnostic methods can yield false positive results. Our test would be fast, reliable, easy-to-perform, and sufficiently low-tech such that it could be implemented in place of the current test and in developing regions that lack advanced medical infrastructure. <br /> <br />
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<p>
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Whooping cough, the infectious respiratory disease caused by <i>Bordetella pertussis</i>, is diagnosed in tens of millions of people and results in almost 300,000 deaths globally each year. Low-income and unvaccinated individuals as well as infants are especially susceptible. Current diagnostic procedures are complicated, costly, and can take up to a week, by which time the disease may have progressed or spread. The enormous impact of this disease urgently motivates the development of a faster, cheaper, and more reliable diagnostic test. Our epidemiology models suggest that earlier diagnosis could drastically reduce the incidence and impact of the disease. We propose an engineered bacteriophage diagnostic system for rapid clinical detection of <i>pertussis</i>. We first engineered T7 bacteriophage to demonstrate this approach in <i>E. coli</i>. Our modular diagnostic approach can be applied to the high-sensitivity detection of other bacteria.
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  <br /> <br />  
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Please let us know if you would like to collaborate or discuss an aspect related to this project. You can can leave a message at igemvirginia at gmail dot com or you can comment below.  
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         site_id: 305006
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Latest revision as of 02:23, 27 October 2012



Logo VGEM

Genetically engineered bacteriophage for diagnosis of whooping cough


Whooping cough, the infectious respiratory disease caused by Bordetella pertussis, is diagnosed in tens of millions of people and results in almost 300,000 deaths globally each year. Low-income and unvaccinated individuals as well as infants are especially susceptible. Current diagnostic procedures are complicated, costly, and can take up to a week, by which time the disease may have progressed or spread. The enormous impact of this disease urgently motivates the development of a faster, cheaper, and more reliable diagnostic test. Our epidemiology models suggest that earlier diagnosis could drastically reduce the incidence and impact of the disease. We propose an engineered bacteriophage diagnostic system for rapid clinical detection of pertussis. We first engineered T7 bacteriophage to demonstrate this approach in E. coli. Our modular diagnostic approach can be applied to the high-sensitivity detection of other bacteria.






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