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Team:SJTU-BioX-Shanghai
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<img src="/wiki/images/2/2e/12SJTU_title_1.png"> | <img src="/wiki/images/2/2e/12SJTU_title_1.png"> | ||
</div> | </div> | ||
- | <div class="entry-content" | + | <div class="entry-content"> |
- | + | <img src="/wiki/images/3/34/12SJTU_entry1.jpg" style="width:320px"></img> | |
- | + | ||
</div> | </div> | ||
+ | <a href="/Team:SJTU-BioX-Shanghai/Project/project2.2"><div id="entry-cover1"> | ||
+ | <p>Membrane Accelerator could help substrates flow by decreasing distance that intermediates have to travel between enzymes. Besides, restricted reaction space on membrane could increase the local products concen- tration near membrane, thus to facilitate the exportation of final products </p> | ||
+ | <p>We successfully increased the yield of fatty acids by 24 fold through building a fatty-acid-producing Mem- brane Accelerator.</p> | ||
+ | </div></a> | ||
</div> | </div> | ||
<div class="main-entry" style="background-color:#4fb1ca; margin-right:26px;"> | <div class="main-entry" style="background-color:#4fb1ca; margin-right:26px;"> | ||
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</div> | </div> | ||
<div class="entry-content"> | <div class="entry-content"> | ||
- | + | <img src="/wiki/images/a/a4/12SJTU_entry2.jpg"></img> | |
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</div> | </div> | ||
+ | <a href="/Team:SJTU-BioX-Shanghai/Project/project2.3"><div id="entry-cover2"> | ||
+ | |||
+ | <p>Previous synthetic scaffold con- trolling metabolic flux all focused on biosynthesis. Now we propose a new direction in the application of syn- thetic scaffold: accelerating biodegradation pathways. </p> | ||
+ | <p>Natural biodegradation is a very slow process but indispensible in environment restoration. Membrane Accelerator is expected to increase rate of biodegrada- tion pathway sharply due to its multiple privileges.</p> | ||
+ | </div></a> | ||
</div> | </div> | ||
<div class="main-entry" style="background-color:#fe88b8;"> | <div class="main-entry" style="background-color:#fe88b8;"> | ||
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</div> | </div> | ||
<div class="entry-content"> | <div class="entry-content"> | ||
- | + | <img src="/wiki/images/2/24/12SJTU_entry3.jpg"></img> | |
- | + | ||
</div> | </div> | ||
+ | <a href="/Team:SJTU-BioX-Shanghai/Project/project2.1"><div id="entry-cover3"> | ||
+ | |||
+ | <p>Dynamically and artificially regulating the direction of biochemical pathway has remained a challenge to all. Based on Membrane Scaffold, we achieved this goal through controlling aggregation state of crucial enzymes in branched reactions with light. This novel device is called Membrane Rudder.</p> | ||
+ | <p>We then further connected the post-translational control system (Membrane Rudder) to genetic circuits and expanded its potential signal pool.</p> | ||
+ | </div></a> | ||
</div> | </div> | ||
</td> | </td> | ||
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- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> The honors we have won:</font></strong> Regional Winner, Best New BioBrick Part or Device Engineered and Gold Medal at Asia Jamboree; Advanced to World Championship.</p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> The breakthrough we made:</font></strong> Redefinition of scaffold in Synthetic Biology by recruiting <i>E.coli’</i>s inner membrane as a natural two-dimensional scaffold. </p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> The system we built:</font></strong> 6 membrane proteins orderly organized on the inner membrane of <i>E.coli</i>, the feasibility of which has been confirmed by fluorescence complementation assay and biosynthesis experiment.</p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> Device 1 we created – Membrane Accelerator:</font></strong> A universal tool that serves to accelerate biochemical reactions in <i>E.coli</i>; Rate of fatty acids synthesis was increased by 24 fold compared to wild-type <i>E.coli </i>and 9 fold compared to <i>E.coli</i> overexpressing cytoplasmic enzymes.</p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> Device 2 we created – Membrane Rudder:</font></strong> A universal tool used to dynamically and artificially control biochemical reactions in <i>E.coli</i>; the direction of Violacein and Deoxyviolacein synthetic pathway was successfully switched through changing blue light signal. </p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> New direction we proposed:</font></strong> The application of scaffold system in accelerating biodegradation pathway by using Membrane Accelerator.</p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> Parts we submitted:</font></strong> 42 well-characterized parts that could either be used directly or serve as a universal tool readily for potential scientific or engineering use.</p> |
- | <p><strong>< | + | <p><strong><img src="/wiki/images/7/73/12SJTU_r.png"><font face="Cambria, serif " size="4"> A club we established – BioCraft:</font></strong> The headquarter of our human practice programs, having come a long way in propagandizing Synthetic Biology and iGEM. Warmly-received activities have been held in and outside the campus. Several celebrities in different fields have shown support for us, laying a cornerstone for our future development.</p> |
</div> | </div> | ||
</div> | </div> | ||
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<div id="team"> | <div id="team"> | ||
<div id="team-title"></div> | <div id="team-title"></div> | ||
- | <div id="team-content"> | + | <a href="/Team:SJTU-BioX-Shanghai/Team/members"><div id="team-content"> |
- | </div> | + | <img src="/wiki/images/b/ba/12SJTU_home_Team.jpg"></img> |
+ | </div></a> | ||
</div> | </div> | ||
<div id="video"> | <div id="video"> | ||
- | < | + | <iframe width="480" height="400" src="http://www.youtube.com/embed/PkE9MtApxAE" frameborder="0" allowfullscreen></iframe> |
</div> | </div> | ||
</td></tr> | </td></tr> | ||
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<tr><td style="border-top-width:40px;"> | <tr><td style="border-top-width:40px;"> | ||
<div id="sponsors"> | <div id="sponsors"> | ||
- | <div id="sponsors-title"><div> | + | <div id="sponsors-title"></div> |
+ | <div id="sponsors-content"> | ||
+ | <table class="sponsorstable" cellspacing="20" ;="" align="center"><tbody> | ||
+ | |||
+ | |||
+ | <tr> | ||
+ | <td> | ||
+ | <a href="http://www.sjtu.edu.cn/"> | ||
+ | <img src="/wiki/images/6/6f/12SJTU_SJTU.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://www.lib.sjtu.edu.cn/"> | ||
+ | <img src="/wiki/images/e/ee/12SJTU_lib.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://www.bio-x.cn"> | ||
+ | <img src="/wiki/images/1/1a/12SJTU_biox.png" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://life.sjtu.edu.cn/"> | ||
+ | <img src="/wiki/images/5/5c/12SJTU_LS.png" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://www.huaqiaofoundation.org/"> | ||
+ | <img src="/wiki/images/6/68/12SJTU_HP3.1.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | </tr> | ||
+ | |||
+ | <tr> | ||
+ | <td> | ||
+ | <a href="http://www.lifetechnologies.com"> | ||
+ | <img src="/wiki/images/d/de/12SJTU_Life_Technology.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://www.genscript.com/"> | ||
+ | <img src="/wiki/images/5/55/12SJTU_genscript_logo.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href="http://www.dnbios.com/"> | ||
+ | <img src="/wiki/images/a/af/12SJTU_DNBIO.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href=""> | ||
+ | <img src="/wiki/images/5/55/12SJTU_shenglianshengwu.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | <td> | ||
+ | <a href=""> | ||
+ | <img src="/wiki/images/f/f0/12SJTU_SHIYI.jpg" style="width: 140px;"> | ||
+ | </a></td> | ||
+ | </tr> | ||
+ | </tbody> | ||
+ | </table> | ||
+ | </div> | ||
</div> | </div> | ||
</td></tr> | </td></tr> |
Latest revision as of 03:58, 27 October 2012
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