Team:Lyon-INSA/results

From 2012.igem.org

(Difference between revisions)
 
(5 intermediate revisions not shown)
Line 39: Line 39:
<div style="float:left;width:680px;margin-left:20px;">
<div style="float:left;width:680px;margin-left:20px;">
<br/><br/>
<br/><br/>
-
Biofilms are responsible for billions of dollars in production losses and treatment costs in the industry every year. Indeed biofilms involve :<br/><br/>
+
Every year industries spend billions of dollars to get rid of the biofilms which develop in their installations. Indeed biofims are reponsible for :<br/><br/>
<li>Food spoilage or poisoning in the food industry<br/>
<li>Food spoilage or poisoning in the food industry<br/>
<li>Pathogens' persistence and dispersal in health industry<br/>
<li>Pathogens' persistence and dispersal in health industry<br/>
<li>Corrosion and diameter reduction of pipelines<br/><br/>
<li>Corrosion and diameter reduction of pipelines<br/><br/>
-
Assuming that the environment is over-saturated with harmful chemicals such as biocides, whose long-term health effects still have to be elucidated, there is a great need for novel solutions to reduce detrimental biofilm effects.<br/>
+
 
 +
At the moment, industries have some solutions at their disposal to limit the biofilm development but they have generaly an environmental impact and/or an important cost.<br/><br/>
 +
 
Thus, we develop a new generation of solution against biofilms in industry, which allows to reduce : <br/><br/>
Thus, we develop a new generation of solution against biofilms in industry, which allows to reduce : <br/><br/>
Line 64: Line 66:
<div class="wrapper">
<div class="wrapper">
   <div class="contenuTexte">
   <div class="contenuTexte">
-
 
+
<div style="float:left;width:680px;margin-left:20px;">
-
<br>
+
<br/>
-
Engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (<strong>KILL</strong>) and protecting the cleaned surfaces by either a surfactant coating (<strong>COAT </strong> option),  
+
Our solution is based on engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (<strong>KILL</strong>) and protecting the cleaned surfaces by either a surfactant coating (<strong>COAT</strong> option), or by establishment of a positive biofilm (<strong> STICK </strong> option).<br/>
-
or by establishment of a positive biofilm (<strong> STICK </strong> option).<br/>
+
<br/>
<br/>
</div>
</div>
<center><img src="https://static.igem.org/mediawiki/2012/c/cb/ModelBs.jpg" width = 450px/></center><br/>
<center><img src="https://static.igem.org/mediawiki/2012/c/cb/ModelBs.jpg" width = 450px/></center><br/>
-
<div style="clear:both"></div>
+
<div style="clear:both"></div><br/>
-
<br/>
+
This tunneling activity of <i>Bacillus subtilis</i> swimmer cells enables to :
-
<br/>
+
<li>Facilitate the delivery of the active substances within the biofilm.</li>
-
<ul>
+
<li>Destroy the inacessible biofilms in pipes.</li><br/>
-
<li>Inacessible biofilms in pipes should be destroyed </li>
+
-
<li>Delivery of active substance within the biofilm should be facilitated by the tunneling activity of <i> Bacillus </i> swimmer cells</li>
+
Moreover <i>Bacillus</i> strains are non pathogenic and do not cause equipment deteroriation by corrosion.
<br/><br/>
<br/><br/>
-
<i>Bacillus</i> strains are:
 
-
<ul>
 
-
<li>non pathogenic </li>
 
-
<li>do not cause equipment deteroriation by corrosion</li>
+
To sum up, this biocide-alternative strategy provides a money-saving and an environementally friendly solution for the control of unwanted biofilm.<br/><br/>
-
<br/><br/>
+
-
This biocide-alternative strategy provides an money-saving and environementally friendly solution for the control of unwanted biofilm<br/><br/>
+
</div>
</div>

Latest revision as of 21:31, 26 October 2012

Context and Objectives



Every year industries spend billions of dollars to get rid of the biofilms which develop in their installations. Indeed biofims are reponsible for :

  • Food spoilage or poisoning in the food industry
  • Pathogens' persistence and dispersal in health industry
  • Corrosion and diameter reduction of pipelines

    At the moment, industries have some solutions at their disposal to limit the biofilm development but they have generaly an environmental impact and/or an important cost.

    Thus, we develop a new generation of solution against biofilms in industry, which allows to reduce :

  • The use of harmful chemical reagents in cleaning processes
  • The cleaning costs for industrialists





    • Click on the title to show/hide the text.

    PROJECT STRATEGY


    Our solution is based on engineered bacterial "torpedos" capable of infiltrating, destroying biofilms (KILL) and protecting the cleaned surfaces by either a surfactant coating (COAT option), or by establishment of a positive biofilm ( STICK option).



    This tunneling activity of Bacillus subtilis swimmer cells enables to :
  • Facilitate the delivery of the active substances within the biofilm.
  • Destroy the inacessible biofilms in pipes.

    • Moreover Bacillus strains are non pathogenic and do not cause equipment deteroriation by corrosion.

    To sum up, this biocide-alternative strategy provides a money-saving and an environementally friendly solution for the control of unwanted biofilm.

    KILL : DESTROY BIOFILM


    LYSOSTAPHIN part BBa_K802000





    DISPERSIN part BBa_K802001



    COMBINED EFFECT


    COAT or STICK : AVOID NEW BIOFILM FORMATION


    SURFACTIN + BIOFILM part BBa_K802009



    AVOID NEW BIOFILM FORMATION

    NEW RESULTS



    Retrieved from "http://2012.igem.org/Team:Lyon-INSA/results"