Team:Peking/Project/3D

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<h3 class="title1">Introduction</h3>
<h3 class="title1">Introduction</h3>
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When used as the input to spatially program cell behavior, the information flow of chemical communication transmits in a diffusive way, which results in uneven distribution and requires a relatively large time scale. The diffusion of chemicals also results in obscure boundaries in chemical printing.<br /><br />Unlike chemical printing, which relies on inducer chemicals to make cells respond, photo-printing is based on beam(s) of parallel light and is able to compensate for what chemical printing lacks. Compared to chemicals, light is also inexpensive. A wide spectrum of light is not toxic to cells and usually cannot introduce interference into intrinsic cellular pathways, which makes photo-printing a safer alternative. With the higher resolution on the spatiotemporal scale, parallel light enables a clear and distinct boundary that is suitable for printing. The incoherence of different parallel light, the coherence of lasers, and the homogeneity of parallel light also enables more detailed prints. The wide spectrum of light provides various options, which in turn allows for more convenient and precise printing. <br /><br />Previously, the main light source for photo-printing in prior studies was the laser, which came with the danger of causing cell damage due to the high energy waves. However, our experiments on photo-printing demonstrated that our parts are sensitive to the luminance in the moon-light scale, which suggests that we might exploit biologically friendly dim light, rather than laser beam (s).
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Optogenetics has a vital advantage that causes it to have a more imperative spot compared with conventional synthetic biology, which based on chemicals in the future of science. Based on light, the information transmits with a high resolution on the spatiotemporal scale, which make detailed work possible.
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Previously, due to the low sensitivity of biosensors,the main light source for optogenetics in prior studies was the laser, which came with the danger of causing cell damage due to the high energy waves. With a higher resolution as well as higher sensitivity, we created the <i>Luminesensor</i>, a valuable compensation for optogenetics, which may make optogenetics in synthetic biology applications no longer a far-off dream.
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Bio-printing is a method that guides a group of cells to response to signals in a highly organised way, which may lay a profound foundation in medical and industrial application (e.g. artificial organ and bio-materials). Detailed printing with living cells requires high spatial resolution, which is difficult to realize with chemicals due to diffusion.
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However, with the <i>Luminesensor</i>, we managed printing with high resolution in 2D and even 3D with the luminance in the moon-light scale, we even managed in detailed printing with the luminance of an iPad, which suggests that it is not only the first artificially designed sensor that responds to the natural light, but also could act as interface between common electrical devices and biological systems.
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  <img src="/wiki/images/7/73/Peking2012_printing_intro.jpg" alt="[Fig 1.]" style="width:500px" />
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Fig 1. Printing result – iGEM logo printed on the bacterial lawn on a agar plate .
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Latest revision as of 05:13, 26 October 2012

Introduction

Optogenetics has a vital advantage that causes it to have a more imperative spot compared with conventional synthetic biology, which based on chemicals in the future of science. Based on light, the information transmits with a high resolution on the spatiotemporal scale, which make detailed work possible.

Previously, due to the low sensitivity of biosensors,the main light source for optogenetics in prior studies was the laser, which came with the danger of causing cell damage due to the high energy waves. With a higher resolution as well as higher sensitivity, we created the Luminesensor, a valuable compensation for optogenetics, which may make optogenetics in synthetic biology applications no longer a far-off dream.

Bio-printing is a method that guides a group of cells to response to signals in a highly organised way, which may lay a profound foundation in medical and industrial application (e.g. artificial organ and bio-materials). Detailed printing with living cells requires high spatial resolution, which is difficult to realize with chemicals due to diffusion.

However, with the Luminesensor, we managed printing with high resolution in 2D and even 3D with the luminance in the moon-light scale, we even managed in detailed printing with the luminance of an iPad, which suggests that it is not only the first artificially designed sensor that responds to the natural light, but also could act as interface between common electrical devices and biological systems.

[Fig 1.]

Fig 1. Printing result – iGEM logo printed on the bacterial lawn on a agar plate .

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